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Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study.

Publication ,  Journal Article
Mechelli, A; Tognin, S; McGuire, PK; Prata, D; Sartori, G; Fusar-Poli, P; De Brito, S; Hariri, AR; Viding, E
Published in: Biological psychiatry
August 2009

The majority of affective psychopathology is rooted early in life and first emerges during childhood and adolescence. However, little is known about how genetic vulnerability affects brain structure and function in childhood since the vast majority of studies published so far have been conducted on adult participants. The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children.Voxel-based morphometry and functional magnetic resonance imaging were used to measure gray matter volume and emotional reactivity in 50 children aged between 10 and 12 years. We tested the hypothesis that met158 allele affects structural brain development and confers heightened reactivity within the affective frontolimbic circuit in children.The met158 allele was positively associated with gray matter volume in the left hippocampal head where genotype accounted for 59% of interindividual variance. In addition, the met158 allele was positively associated with neuronal responses to fearful relative to neutral facial expressions in the right parahippocampal gyrus where genotype accounted for 14% of the interindividual variance.These results indicate that the met158 allele is associated with increased gray matter volume and heightened reactivity during emotional processing within the limbic system in children as young as 10 to 12 years of age. These findings are consistent with the notion that genetic factors affect brain function to moderate vulnerability to affective psychopathology from childhood.

Duke Scholars

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

August 2009

Volume

66

Issue

3

Start / End Page

231 / 237

Related Subject Headings

  • Valine
  • Twin Studies as Topic
  • Reaction Time
  • Psychiatry
  • Polymorphism, Genetic
  • Photic Stimulation
  • Oxygen
  • Neuropsychological Tests
  • Methionine
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Mechelli, A., Tognin, S., McGuire, P. K., Prata, D., Sartori, G., Fusar-Poli, P., … Viding, E. (2009). Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. Biological Psychiatry, 66(3), 231–237. https://doi.org/10.1016/j.biopsych.2009.01.033
Mechelli, Andrea, Stefania Tognin, Philip K. McGuire, Diana Prata, Giuseppe Sartori, Paolo Fusar-Poli, Stephane De Brito, Ahmad R. Hariri, and Essi Viding. “Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study.Biological Psychiatry 66, no. 3 (August 2009): 231–37. https://doi.org/10.1016/j.biopsych.2009.01.033.
Mechelli A, Tognin S, McGuire PK, Prata D, Sartori G, Fusar-Poli P, et al. Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. Biological psychiatry. 2009 Aug;66(3):231–7.
Mechelli, Andrea, et al. “Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study.Biological Psychiatry, vol. 66, no. 3, Aug. 2009, pp. 231–37. Epmc, doi:10.1016/j.biopsych.2009.01.033.
Mechelli A, Tognin S, McGuire PK, Prata D, Sartori G, Fusar-Poli P, De Brito S, Hariri AR, Viding E. Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. Biological psychiatry. 2009 Aug;66(3):231–237.
Journal cover image

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

August 2009

Volume

66

Issue

3

Start / End Page

231 / 237

Related Subject Headings

  • Valine
  • Twin Studies as Topic
  • Reaction Time
  • Psychiatry
  • Polymorphism, Genetic
  • Photic Stimulation
  • Oxygen
  • Neuropsychological Tests
  • Methionine
  • Male