Skip to main content
Journal cover image

Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic.

Publication ,  Journal Article
Lyketsos, CG; Corazzini, K; Steele, CD; Kraus, MF
Published in: The Journal of neuropsychiatry and clinical neurosciences
January 1996

The efficacy of tacrine for treatment of Alzheimer's has been demonstrated in several clinical trials but has not been assessed in cases complicated by medical and psychiatric comorbidities. Additionally, the benefit-risk ratio of tacrine is small, so it is best administered with carefully developed guidelines that specify this ratio for patients and families. On the basis of guidelines developed for the Johns Hopkins Dementia Research Clinic, tacrine treatment was offered to 162 patients with probable Alzheimer's. Only 35 accepted, and only 22 continued on tacrine beyond 3 months. The latter group declined by 1.36 points over 1 year on the Mini-Mental State Examination, significantly less than expected. The authors conclude that, if used in the context of clinical guidelines, tacrine is an effective treatment for Alzheimer's.

Duke Scholars

Published In

The Journal of neuropsychiatry and clinical neurosciences

DOI

EISSN

1545-7222

ISSN

0895-0172

Publication Date

January 1996

Volume

8

Issue

1

Start / End Page

67 / 73

Related Subject Headings

  • Treatment Outcome
  • Tacrine
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Nootropic Agents
  • Mental Disorders
  • Male
  • Humans
  • Female
  • Comorbidity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lyketsos, C. G., Corazzini, K., Steele, C. D., & Kraus, M. F. (1996). Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic. The Journal of Neuropsychiatry and Clinical Neurosciences, 8(1), 67–73. https://doi.org/10.1176/jnp.8.1.67
Lyketsos, C. G., K. Corazzini, C. D. Steele, and M. F. Kraus. “Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic.The Journal of Neuropsychiatry and Clinical Neurosciences 8, no. 1 (January 1996): 67–73. https://doi.org/10.1176/jnp.8.1.67.
Lyketsos CG, Corazzini K, Steele CD, Kraus MF. Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic. The Journal of neuropsychiatry and clinical neurosciences. 1996 Jan;8(1):67–73.
Lyketsos, C. G., et al. “Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic.The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 8, no. 1, Jan. 1996, pp. 67–73. Epmc, doi:10.1176/jnp.8.1.67.
Lyketsos CG, Corazzini K, Steele CD, Kraus MF. Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic. The Journal of neuropsychiatry and clinical neurosciences. 1996 Jan;8(1):67–73.
Journal cover image

Published In

The Journal of neuropsychiatry and clinical neurosciences

DOI

EISSN

1545-7222

ISSN

0895-0172

Publication Date

January 1996

Volume

8

Issue

1

Start / End Page

67 / 73

Related Subject Headings

  • Treatment Outcome
  • Tacrine
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Nootropic Agents
  • Mental Disorders
  • Male
  • Humans
  • Female
  • Comorbidity