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Macroautophagy in T lymphocyte development and function.

Publication ,  Journal Article
He, M-X; McLeod, IX; Jia, W; He, Y-W
Published in: Front Immunol
2012

Macroautophagy (referred to as autophagy) is a fundamental intracellular process characterized by the sequestration of cytoplasmic compartments through double-membrane vesicles, termed autophagosomes. Recent studies have established important roles of autophagy in regulating T lymphocyte development and function. Resting T lymphocytes have basal levels of autophagy that is upregulated by T cell receptor stimulation. Several specific knockout or transgenic models have been developed during the past few years, and it has been revealed that autophagy plays an essential role in regulating thymocyte selection, peripheral T cell survival, and proliferation. The regulation of T cell development and function by autophagy is mediated through its role in regulating self-antigen presentation, intracellular organelle homeostasis, and energy production. Here we will review the current findings concerning how autophagy regulates T cell function, as well as compare different models in studying autophagy in T lymphocytes.

Duke Scholars

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2012

Volume

3

Start / End Page

22

Location

Switzerland

Related Subject Headings

  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology
 

Citation

APA
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ICMJE
MLA
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He, M.-X., McLeod, I. X., Jia, W., & He, Y.-W. (2012). Macroautophagy in T lymphocyte development and function. Front Immunol, 3, 22. https://doi.org/10.3389/fimmu.2012.00022
He, Ming-Xiao, Ian X. McLeod, Wei Jia, and You-Wen He. “Macroautophagy in T lymphocyte development and function.Front Immunol 3 (2012): 22. https://doi.org/10.3389/fimmu.2012.00022.
He M-X, McLeod IX, Jia W, He Y-W. Macroautophagy in T lymphocyte development and function. Front Immunol. 2012;3:22.
He, Ming-Xiao, et al. “Macroautophagy in T lymphocyte development and function.Front Immunol, vol. 3, 2012, p. 22. Pubmed, doi:10.3389/fimmu.2012.00022.
He M-X, McLeod IX, Jia W, He Y-W. Macroautophagy in T lymphocyte development and function. Front Immunol. 2012;3:22.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2012

Volume

3

Start / End Page

22

Location

Switzerland

Related Subject Headings

  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology