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The contribution of autophagy to lymphocyte survival and homeostasis.

Publication ,  Journal Article
McLeod, IX; Jia, W; He, Y-W
Published in: Immunol Rev
September 2012

Over the life span of a T lymphocyte, from thymic development to death, it is subjected to a variety of stresses and stimuli. Upon receipt of each stress or stimulus, a potentially life-changing fate decision must be made, namely, whether to commit to a form of programmed cell death or to make the necessary adaptations to effectively deal with the changing environment. In our laboratory, we have identified several stresses that a T lymphocyte will encounter during a normal life span. Our studies have focused on how T cells utilize autophagy to get a grasp on the situation, or in cases in which survival is untenable, how T cells use autophagy to hasten their demise. This review focuses on the functions of T-cell autophagy in maintaining homeostasis, eliminating excess or dangerous levels of mitochondria, trimming levels of endoplasmic reticulum, and promoting a healthy metabolic level to allow cells to perform as productive components of the immune system. In addition, the use of autophagy signaling molecules to perform autophagy-independent tasks involved in the maintenance of immune homeostasis is discussed.

Duke Scholars

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

September 2012

Volume

249

Issue

1

Start / End Page

195 / 204

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Signal Transduction
  • Mitochondria
  • Immunology
  • Humans
  • Homeostasis
  • Energy Metabolism
  • Endoplasmic Reticulum
  • B-Lymphocytes
  • Autophagy
 

Citation

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McLeod, I. X., Jia, W., & He, Y.-W. (2012). The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev, 249(1), 195–204. https://doi.org/10.1111/j.1600-065X.2012.01143.x
McLeod, Ian X., Wei Jia, and You-Wen He. “The contribution of autophagy to lymphocyte survival and homeostasis.Immunol Rev 249, no. 1 (September 2012): 195–204. https://doi.org/10.1111/j.1600-065X.2012.01143.x.
McLeod IX, Jia W, He Y-W. The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev. 2012 Sep;249(1):195–204.
McLeod, Ian X., et al. “The contribution of autophagy to lymphocyte survival and homeostasis.Immunol Rev, vol. 249, no. 1, Sept. 2012, pp. 195–204. Pubmed, doi:10.1111/j.1600-065X.2012.01143.x.
McLeod IX, Jia W, He Y-W. The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev. 2012 Sep;249(1):195–204.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

September 2012

Volume

249

Issue

1

Start / End Page

195 / 204

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Signal Transduction
  • Mitochondria
  • Immunology
  • Humans
  • Homeostasis
  • Energy Metabolism
  • Endoplasmic Reticulum
  • B-Lymphocytes
  • Autophagy