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Platelet activation and its patient-specific consequences.

Publication ,  Journal Article
Smyth, SS; Monroe, DM; Wysokinski, WE; McBane, RD; Whiteheart, SW; Becker, RC; Steinhubl, SR
Published in: Thrombosis research
January 2008

Individuals vary in their thrombotic response to vascular injury. The reasons for this are numerous, involving heterogeneity in multiple platelet responses. Platelet research has tended to focus on functioning at the molecular level, and many experiments reflect results obtained in isolated, in vitro systems. However, platelets function in a complex and dynamic in vivo environment with the potential for a wide range of biological influences. This article reviews the evidence for diversity in platelet responses and the implications for individual variability in propensity to arterial thrombosis. Three overarching phenomena are considered. First, platelets can vary quantitatively and qualitatively in their responses to agonists. Second, platelets appear to have different intrinsic levels of procoagulant activity. Third, responses to various procoagulant, regulatory, and mediating factors likewise differ within and among individuals and can be influenced by blood-borne factors. These phenomena may help to explain differences in experimental arterial thrombosis observed in individuals.

Duke Scholars

Published In

Thrombosis research

DOI

EISSN

1879-2472

ISSN

0049-3848

Publication Date

January 2008

Volume

122

Issue

4

Start / End Page

435 / 441

Related Subject Headings

  • Time Factors
  • Thrombosis
  • Thrombin
  • Swine
  • Platelet Count
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Platelet Activation
  • Models, Biological
  • Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
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Smyth, S. S., Monroe, D. M., Wysokinski, W. E., McBane, R. D., Whiteheart, S. W., Becker, R. C., & Steinhubl, S. R. (2008). Platelet activation and its patient-specific consequences. Thrombosis Research, 122(4), 435–441. https://doi.org/10.1016/j.thromres.2007.08.023
Smyth, Susan S., Dougald M. Monroe, Waldemar E. Wysokinski, Robert D. McBane, Sidney W. Whiteheart, Richard C. Becker, and Steven R. Steinhubl. “Platelet activation and its patient-specific consequences.Thrombosis Research 122, no. 4 (January 2008): 435–41. https://doi.org/10.1016/j.thromres.2007.08.023.
Smyth SS, Monroe DM, Wysokinski WE, McBane RD, Whiteheart SW, Becker RC, et al. Platelet activation and its patient-specific consequences. Thrombosis research. 2008 Jan;122(4):435–41.
Smyth, Susan S., et al. “Platelet activation and its patient-specific consequences.Thrombosis Research, vol. 122, no. 4, Jan. 2008, pp. 435–41. Epmc, doi:10.1016/j.thromres.2007.08.023.
Smyth SS, Monroe DM, Wysokinski WE, McBane RD, Whiteheart SW, Becker RC, Steinhubl SR. Platelet activation and its patient-specific consequences. Thrombosis research. 2008 Jan;122(4):435–441.
Journal cover image

Published In

Thrombosis research

DOI

EISSN

1879-2472

ISSN

0049-3848

Publication Date

January 2008

Volume

122

Issue

4

Start / End Page

435 / 441

Related Subject Headings

  • Time Factors
  • Thrombosis
  • Thrombin
  • Swine
  • Platelet Count
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Platelet Activation
  • Models, Biological
  • Lymphocytes