Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures.
Publication
, Journal Article
Chen, YT; Ding, JH
Published in: Biochem Biophys Res Commun
March 30, 1987
Two fat soluble vitamins, Vitamins E and K, when added into culture medium, were found to increase aryl hydrocarbon hydroxylase activity in human cultured cells. The extent of induction in a hepatoma-derived cell line (Hep G2) by these vitamins is of similar magnitude to those cells receiving benz[a]anthracene; whereas in a mammary tumor-derived cell line (MCF-7), benz[a]anthracene is the best inducer for the hydroxylase activity. The increase of the hydroxylase activity is associated with increased levels of a specific mRNA coding for polynuclear aromatic hydrocarbons-induced form of cytochrome P-450 with Vitamins E and K treatment. The size of the induced mRNA is 3.3 kilobase which is the same as that of benz[a]anthracene treatment.
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Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
March 30, 1987
Volume
143
Issue
3
Start / End Page
863 / 871
Location
United States
Related Subject Headings
- Vitamin K
- Vitamin E
- Liver Neoplasms
- Kinetics
- Humans
- Enzyme Induction
- Cell Line
- Carcinoma, Hepatocellular
- Breast Neoplasms
- Biochemistry & Molecular Biology
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Chen, Y. T., & Ding, J. H. (1987). Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures. Biochem Biophys Res Commun, 143(3), 863–871. https://doi.org/10.1016/0006-291x(87)90329-9
Chen, Y. T., and J. H. Ding. “Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures.” Biochem Biophys Res Commun 143, no. 3 (March 30, 1987): 863–71. https://doi.org/10.1016/0006-291x(87)90329-9.
Chen YT, Ding JH. Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures. Biochem Biophys Res Commun. 1987 Mar 30;143(3):863–71.
Chen, Y. T., and J. H. Ding. “Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures.” Biochem Biophys Res Commun, vol. 143, no. 3, Mar. 1987, pp. 863–71. Pubmed, doi:10.1016/0006-291x(87)90329-9.
Chen YT, Ding JH. Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures. Biochem Biophys Res Commun. 1987 Mar 30;143(3):863–871.
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
March 30, 1987
Volume
143
Issue
3
Start / End Page
863 / 871
Location
United States
Related Subject Headings
- Vitamin K
- Vitamin E
- Liver Neoplasms
- Kinetics
- Humans
- Enzyme Induction
- Cell Line
- Carcinoma, Hepatocellular
- Breast Neoplasms
- Biochemistry & Molecular Biology