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Liver-specific glucose-6-phosphatase is not present in human placenta.

Publication ,  Journal Article
Chen, YT; Kato, T
Published in: J Inherit Metab Dis
1985

Type I glycogen storage disease (McKusick 23220), an inherited absence or deficiency of glucose-6-phosphatase (EC 3.1.3.9) activity in the liver, kidney and intestine, is associated with the accumulation of glycogen in those organs. Previous reports have shown that glucose-6-phosphatase exists in human placenta and that detection of a heterozygote for this disorder from placenta might be possible. Our finding of a normal glucose-6-phosphatase activity in a placenta from a patient at risk for type Ia glycogen storage disease prompted us to examine in more detail placental glucose-6-phosphatase. Unexpectedly, we found the properties of the placental enzyme differed from that in normal liver, and the placental enzyme hydrolyzed glucose-6-phosphate, mannose-6-phosphate, beta-glycerol phosphate and glucose-1-phosphate equally well. Our data suggest the enzyme deficient in type I glycogen storage disease cannot be detected in placenta.

Duke Scholars

Published In

J Inherit Metab Dis

DOI

ISSN

0141-8955

Publication Date

1985

Volume

8

Issue

2

Start / End Page

92 / 94

Location

United States

Related Subject Headings

  • Prenatal Diagnosis
  • Pregnancy
  • Placenta
  • Liver
  • Humans
  • Glycogen Storage Disease Type I
  • Glucose-6-Phosphatase
  • Genetics & Heredity
  • Fetal Diseases
  • Female
 

Citation

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Chen, Y. T., & Kato, T. (1985). Liver-specific glucose-6-phosphatase is not present in human placenta. J Inherit Metab Dis, 8(2), 92–94. https://doi.org/10.1007/BF01801675
Chen, Y. T., and T. Kato. “Liver-specific glucose-6-phosphatase is not present in human placenta.J Inherit Metab Dis 8, no. 2 (1985): 92–94. https://doi.org/10.1007/BF01801675.
Chen YT, Kato T. Liver-specific glucose-6-phosphatase is not present in human placenta. J Inherit Metab Dis. 1985;8(2):92–4.
Chen, Y. T., and T. Kato. “Liver-specific glucose-6-phosphatase is not present in human placenta.J Inherit Metab Dis, vol. 8, no. 2, 1985, pp. 92–94. Pubmed, doi:10.1007/BF01801675.
Chen YT, Kato T. Liver-specific glucose-6-phosphatase is not present in human placenta. J Inherit Metab Dis. 1985;8(2):92–94.
Journal cover image

Published In

J Inherit Metab Dis

DOI

ISSN

0141-8955

Publication Date

1985

Volume

8

Issue

2

Start / End Page

92 / 94

Location

United States

Related Subject Headings

  • Prenatal Diagnosis
  • Pregnancy
  • Placenta
  • Liver
  • Humans
  • Glycogen Storage Disease Type I
  • Glucose-6-Phosphatase
  • Genetics & Heredity
  • Fetal Diseases
  • Female