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Reduction in oocyte number following prenatal exposure to a diet high in galactose.

Publication ,  Journal Article
Chen, YT; Mattison, DR; Feigenbaum, L; Fukui, H; Schulman, JD
Published in: Science
December 4, 1981

When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.

Duke Scholars

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 4, 1981

Volume

214

Issue

4525

Start / End Page

1145 / 1147

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Ovum
  • Oocytes
  • Maternal-Fetal Exchange
  • General Science & Technology
  • Galactose
  • Fetus
  • Female
 

Citation

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Chen, Y. T., Mattison, D. R., Feigenbaum, L., Fukui, H., & Schulman, J. D. (1981). Reduction in oocyte number following prenatal exposure to a diet high in galactose. Science, 214(4525), 1145–1147. https://doi.org/10.1126/science.7302587
Chen, Y. T., D. R. Mattison, L. Feigenbaum, H. Fukui, and J. D. Schulman. “Reduction in oocyte number following prenatal exposure to a diet high in galactose.Science 214, no. 4525 (December 4, 1981): 1145–47. https://doi.org/10.1126/science.7302587.
Chen YT, Mattison DR, Feigenbaum L, Fukui H, Schulman JD. Reduction in oocyte number following prenatal exposure to a diet high in galactose. Science. 1981 Dec 4;214(4525):1145–7.
Chen, Y. T., et al. “Reduction in oocyte number following prenatal exposure to a diet high in galactose.Science, vol. 214, no. 4525, Dec. 1981, pp. 1145–47. Pubmed, doi:10.1126/science.7302587.
Chen YT, Mattison DR, Feigenbaum L, Fukui H, Schulman JD. Reduction in oocyte number following prenatal exposure to a diet high in galactose. Science. 1981 Dec 4;214(4525):1145–1147.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 4, 1981

Volume

214

Issue

4525

Start / End Page

1145 / 1147

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Ovum
  • Oocytes
  • Maternal-Fetal Exchange
  • General Science & Technology
  • Galactose
  • Fetus
  • Female