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Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy.

Publication ,  Journal Article
Osbakken, M; Douglas, PS; Ivanics, T; Zhang, DN; Van Winkle, T
Published in: J Am Coll Cardiol
January 1992

To determine whether cardiac hypertrophy secondary to chronic renovascular hypertension is associated with altered in vivo myocardial metabolism, phosphorus-31 nuclear magnetic resonance saturation transfer techniques were used to study creatine kinase (CK) kinetics in six chronically hypertensive dogs with moderate cardiac hypertrophy and eight control dogs. The forward rate constant of CK and the flux of phosphocreatine to adenosine triphosphate were determined in both groups of dogs before and during norepinephrine administration (1 microgram/kg per min), used to increase heart rate x systolic blood pressure (rate-pressure product), cardiac output and oxygen consumption. Baseline and norepinephrine-induced changes in rate-pressure product, cardiac output and oxygen consumption were similar in both groups of dogs, as were baseline forward rate constant and flux of phosphocreatine to adenosine triphosphate. However, the norepinephrine-induced changes in forward rate constant and flux were significantly less in hypertensive than in control dogs (p less than 0.05) even though changes in hemodynamic and functional variables were similar in both groups. These data demonstrate that moderate myocardial hypertrophy is associated with altered CK kinetics, which do not appear to affect the heart's ability for global mechanical recruitment at this stage in the hypertensive process. It is possible that the changes in myocardial enzyme kinetics may contribute to diastolic dysfunction previously reported in this model and may be a precursor for ultimate development of heart failure if hypertension is maintained for prolonged periods.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

January 1992

Volume

19

Issue

1

Start / End Page

223 / 228

Location

United States

Related Subject Headings

  • Phosphorus Radioisotopes
  • Phosphocreatine
  • Myocardium
  • Magnetic Resonance Spectroscopy
  • Kinetics
  • Hypertension, Renovascular
  • Heart
  • Epinephrine
  • Echocardiography
  • Dogs
 

Citation

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Osbakken, M., Douglas, P. S., Ivanics, T., Zhang, D. N., & Van Winkle, T. (1992). Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy. J Am Coll Cardiol, 19(1), 223–228. https://doi.org/10.1016/0735-1097(92)90076-y
Osbakken, M., P. S. Douglas, T. Ivanics, D. N. Zhang, and T. Van Winkle. “Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy.J Am Coll Cardiol 19, no. 1 (January 1992): 223–28. https://doi.org/10.1016/0735-1097(92)90076-y.
Osbakken M, Douglas PS, Ivanics T, Zhang DN, Van Winkle T. Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy. J Am Coll Cardiol. 1992 Jan;19(1):223–8.
Osbakken, M., et al. “Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy.J Am Coll Cardiol, vol. 19, no. 1, Jan. 1992, pp. 223–28. Pubmed, doi:10.1016/0735-1097(92)90076-y.
Osbakken M, Douglas PS, Ivanics T, Zhang DN, Van Winkle T. Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy. J Am Coll Cardiol. 1992 Jan;19(1):223–228.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

January 1992

Volume

19

Issue

1

Start / End Page

223 / 228

Location

United States

Related Subject Headings

  • Phosphorus Radioisotopes
  • Phosphocreatine
  • Myocardium
  • Magnetic Resonance Spectroscopy
  • Kinetics
  • Hypertension, Renovascular
  • Heart
  • Epinephrine
  • Echocardiography
  • Dogs