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Alterations in diastolic function in response to progressive left ventricular hypertrophy.

Publication ,  Journal Article
Douglas, PS; Berko, B; Lesh, M; Reichek, N
Published in: J Am Coll Cardiol
February 1989

To examine the time course of the functional consequences of progressive left ventricular hypertrophy, diastolic left ventricular inflow and wall thinning variables were analyzed in 13 dogs before and 2, 4, 8 and 12 weeks after creation of perinephritic hypertension. Left ventricular echocardiograms were digitized for dimensions, mass and peak rates of wall thinning (-dh/dt/h) and cavity enlargement (dD/dt/D). Doppler recordings of left ventricular inflow were analyzed for peak early (E) and late (A) diastolic inflow velocities, their ratio and atrial filling fraction. At 2 weeks, systolic blood pressure increased from 151 to 233 mm Hg, wall stress from 52 to 80 kdynes/cm2 and posterior wall thickness from 0.68 to 0.84 cm (all p less than 0.05). Left ventricular mass increased from 90 to 115 g over 12 weeks (p less than 0.05). Heart rate, cavity size and systolic shortening were unchanged at all data points. Diastolic abnormalities accompanied the developing hypertrophy and included impairment of early function, as demonstrated by a peak rate of wall thinning, from -13.4 to -8.9 l/s at 2 weeks (p less than 0.05), increased dependence on atrial systolic filling, a decrease in E/A from 1.68 to 1.29 at 4 weeks (p less than 0.05) and an increase in atrial filling fraction from 30% to 43% at 8 weeks (p = NS). Thus, diastolic dysfunction is an early consequence of experimental left ventricular hypertrophy. Different aspects of diastolic impairment are sensitively reflected by echocardiographic Doppler recordings, suggesting that these methods should be useful for the detection of diastolic dysfunction in human patients.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

February 1989

Volume

13

Issue

2

Start / End Page

461 / 467

Location

United States

Related Subject Headings

  • Myocardial Contraction
  • Hypertension
  • Heart Ventricles
  • Echocardiography, Doppler
  • Dogs
  • Diastole
  • Cardiovascular System & Hematology
  • Cardiomegaly
  • Blood Flow Velocity
  • Animals
 

Citation

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Douglas, P. S., Berko, B., Lesh, M., & Reichek, N. (1989). Alterations in diastolic function in response to progressive left ventricular hypertrophy. J Am Coll Cardiol, 13(2), 461–467. https://doi.org/10.1016/0735-1097(89)90527-5
Douglas, P. S., B. Berko, M. Lesh, and N. Reichek. “Alterations in diastolic function in response to progressive left ventricular hypertrophy.J Am Coll Cardiol 13, no. 2 (February 1989): 461–67. https://doi.org/10.1016/0735-1097(89)90527-5.
Douglas PS, Berko B, Lesh M, Reichek N. Alterations in diastolic function in response to progressive left ventricular hypertrophy. J Am Coll Cardiol. 1989 Feb;13(2):461–7.
Douglas, P. S., et al. “Alterations in diastolic function in response to progressive left ventricular hypertrophy.J Am Coll Cardiol, vol. 13, no. 2, Feb. 1989, pp. 461–67. Pubmed, doi:10.1016/0735-1097(89)90527-5.
Douglas PS, Berko B, Lesh M, Reichek N. Alterations in diastolic function in response to progressive left ventricular hypertrophy. J Am Coll Cardiol. 1989 Feb;13(2):461–467.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

February 1989

Volume

13

Issue

2

Start / End Page

461 / 467

Location

United States

Related Subject Headings

  • Myocardial Contraction
  • Hypertension
  • Heart Ventricles
  • Echocardiography, Doppler
  • Dogs
  • Diastole
  • Cardiovascular System & Hematology
  • Cardiomegaly
  • Blood Flow Velocity
  • Animals