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Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression

Publication ,  Journal Article
Rosewicz, S; Lewis, LD; Liddle, RA; Logsdon, CD
Published in: American Journal of Physiology - Gastrointestinal and Liver Physiology
December 1, 1988

The effects of cholecystokinin (CCK) on pancreatic ornithine decarboxylase (ODC) gene expression were studied in the rat. Plasma CCK concentrations were raised to levels comparable to postprandial values either by intravenous infusion of CCK octapeptide (CCK-8) or by intraduodenal perfusion of soybean trypsin inhibitor (SBTI). ODC mRNA levels were quantified using a cloned cDNA probe. ODC mRNA increased to 166 ± 34% (n = 4) of control after 1 h, peaked at 254 ± 39% (n = 4) of control after 24 h, and remained significantly elevated for up to 48 h of SBTI infusion. Intravenous infusion of CCK-8 for 24 h increased ODC mRNA levels of the same extent observed with SBTI infusion. The CCK receptor antagonist L364,718 by itself had no effect on ODC mRNA by both intravenous CCK infusion and intraduodenal infusion of SBTI. These data therefore indicate that CCK plasma concentrations comparable to postprandial values regulate pancreatic ODC at a pretranslational level and that SBTI exerts its effects on pancreatic ODC via an increase in plasma CCK.

Duke Scholars

Published In

American Journal of Physiology - Gastrointestinal and Liver Physiology

ISSN

0002-9513

Publication Date

December 1, 1988

Volume

255

Issue

6

Related Subject Headings

  • Cardiovascular System & Hematology
 

Citation

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ICMJE
MLA
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Rosewicz, S., Lewis, L. D., Liddle, R. A., & Logsdon, C. D. (1988). Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression. American Journal of Physiology - Gastrointestinal and Liver Physiology, 255(6).
Rosewicz, S., L. D. Lewis, R. A. Liddle, and C. D. Logsdon. “Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression.” American Journal of Physiology - Gastrointestinal and Liver Physiology 255, no. 6 (December 1, 1988).
Rosewicz S, Lewis LD, Liddle RA, Logsdon CD. Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression. American Journal of Physiology - Gastrointestinal and Liver Physiology. 1988 Dec 1;255(6).
Rosewicz, S., et al. “Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression.” American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 255, no. 6, Dec. 1988.
Rosewicz S, Lewis LD, Liddle RA, Logsdon CD. Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression. American Journal of Physiology - Gastrointestinal and Liver Physiology. 1988 Dec 1;255(6).

Published In

American Journal of Physiology - Gastrointestinal and Liver Physiology

ISSN

0002-9513

Publication Date

December 1, 1988

Volume

255

Issue

6

Related Subject Headings

  • Cardiovascular System & Hematology