Amoxapine: A review of literature
Publication
, Journal Article
Ban, TA; Wilson, WH; McEvoy, JP
Published in: International Pharmacopsychiatry
1980
Amoxapine, a new antidepressant, is a tricyclic dibenzoxazepine compound, the demethylated metabolite of the neuroleptic loxapine. In animal pharmacological studies, amoxapine has shown striking similarities to imipramine. In contrast to the prototype anti-depressant drug, however, amoxapine does not interact with serotonin. In 10 uncontrolled clinical trials amoxapine was shown to have antidepressant effects in the dosage range of 100-300 mg/day. This was verified in 10 published standard, and placebo and standard controlled clinical studies in which amoxapine was superior to placebo and equal in overall therapeutic efficacy to imipramine and amitriptyline. Side effects were similar to the reference drugs.
Duke Scholars
Published In
International Pharmacopsychiatry
Publication Date
1980
Volume
15
Issue
3
Start / End Page
166 / 170
Related Subject Headings
- Psychiatry
- 1702 Cognitive Sciences
- 1109 Neurosciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Ban, T. A., Wilson, W. H., & McEvoy, J. P. (1980). Amoxapine: A review of literature. International Pharmacopsychiatry, 15(3), 166–170.
Ban, T. A., W. H. Wilson, and J. P. McEvoy. “Amoxapine: A review of literature.” International Pharmacopsychiatry 15, no. 3 (1980): 166–70.
Ban TA, Wilson WH, McEvoy JP. Amoxapine: A review of literature. International Pharmacopsychiatry. 1980;15(3):166–70.
Ban, T. A., et al. “Amoxapine: A review of literature.” International Pharmacopsychiatry, vol. 15, no. 3, 1980, pp. 166–70.
Ban TA, Wilson WH, McEvoy JP. Amoxapine: A review of literature. International Pharmacopsychiatry. 1980;15(3):166–170.
Published In
International Pharmacopsychiatry
Publication Date
1980
Volume
15
Issue
3
Start / End Page
166 / 170
Related Subject Headings
- Psychiatry
- 1702 Cognitive Sciences
- 1109 Neurosciences
- 1103 Clinical Sciences