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Topical clobetasol-17-propionate: review of its clinical efficacy and safety.

Publication ,  Journal Article
Olsen, EA; Cornell, RC
Published in: J Am Acad Dermatol
August 1986

Clobetasol-17-propionate, the most potent of currently available topical steroids as predicted by the vasoconstrictor assay, has just been approved in the United States. In psoriasis, it has proved significantly more effective than class II steroids and as or more effective than the only marketed class I steroid. In the more steroid-responsive eczemas, the superior efficacy of clobetasol is also apparent, but less striking. Clobetasol prolongs remission rates, making intermittent treatment schedules feasible and minimizing inherent potential steroid side effects. Clobetasol may also be useful in the treatment of a myriad of other skin conditions. A review of the pharmacology, efficacy, and side effects of this addition to our dermatologic armamentarium is presented here.

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Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1986

Volume

15

Issue

2 Pt 1

Start / End Page

246 / 255

Location

United States

Related Subject Headings

  • Psoriasis
  • Pituitary-Adrenal System
  • Hypothalamo-Hypophyseal System
  • Eczema
  • Drug Administration Schedule
  • Dermatology & Venereal Diseases
  • Combined Modality Therapy
  • Clobetasol
  • Betamethasone
  • Administration, Topical
 

Citation

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Olsen, E. A., & Cornell, R. C. (1986). Topical clobetasol-17-propionate: review of its clinical efficacy and safety. J Am Acad Dermatol, 15(2 Pt 1), 246–255. https://doi.org/10.1016/s0190-9622(86)70164-3
Olsen, E. A., and R. C. Cornell. “Topical clobetasol-17-propionate: review of its clinical efficacy and safety.J Am Acad Dermatol 15, no. 2 Pt 1 (August 1986): 246–55. https://doi.org/10.1016/s0190-9622(86)70164-3.
Olsen EA, Cornell RC. Topical clobetasol-17-propionate: review of its clinical efficacy and safety. J Am Acad Dermatol. 1986 Aug;15(2 Pt 1):246–55.
Olsen, E. A., and R. C. Cornell. “Topical clobetasol-17-propionate: review of its clinical efficacy and safety.J Am Acad Dermatol, vol. 15, no. 2 Pt 1, Aug. 1986, pp. 246–55. Pubmed, doi:10.1016/s0190-9622(86)70164-3.
Olsen EA, Cornell RC. Topical clobetasol-17-propionate: review of its clinical efficacy and safety. J Am Acad Dermatol. 1986 Aug;15(2 Pt 1):246–255.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1986

Volume

15

Issue

2 Pt 1

Start / End Page

246 / 255

Location

United States

Related Subject Headings

  • Psoriasis
  • Pituitary-Adrenal System
  • Hypothalamo-Hypophyseal System
  • Eczema
  • Drug Administration Schedule
  • Dermatology & Venereal Diseases
  • Combined Modality Therapy
  • Clobetasol
  • Betamethasone
  • Administration, Topical