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Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.

Publication ,  Journal Article
Petes, TD; Botstein, D
Published in: Proc Natl Acad Sci U S A
November 1977

A diploid strain of yeast (Saccharomyces cerevisiae) was found to be heterozygous for two forms of the highly repetitious ribosomal DNA. These forms could be distinguished by the pattern of fragments produced after digestion with the site-specific restriction endonuclease EcoRI. The mode of inheritance of ribosomal DNA was determined by tetrad analysis. Of 14 tetrads analyzed, 12 clearly showed the ribosomal DNA forms segregating as a single Mendelian unit. The simplest interpretation of this result is that all of the approximately 100 copies of the ribosomal DNA genes of the yeast cell are located on one chromosome and that meiotic recombination within these genes is suppressed. Two of the 14 tetrads showed the segregation patterns expected as the result of mitotic recombination within the ribosomal DNA.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 1977

Volume

74

Issue

11

Start / End Page

5091 / 5095

Location

United States

Related Subject Headings

  • Spores, Fungal
  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Nucleic Acid Hybridization
  • Mitosis
  • DNA
  • Chromosomes
  • Base Sequence
 

Citation

APA
Chicago
ICMJE
MLA
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Petes, T. D., & Botstein, D. (1977). Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. Proc Natl Acad Sci U S A, 74(11), 5091–5095. https://doi.org/10.1073/pnas.74.11.5091
Petes, T. D., and D. Botstein. “Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.Proc Natl Acad Sci U S A 74, no. 11 (November 1977): 5091–95. https://doi.org/10.1073/pnas.74.11.5091.
Petes TD, Botstein D. Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5091–5.
Petes, T. D., and D. Botstein. “Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.Proc Natl Acad Sci U S A, vol. 74, no. 11, Nov. 1977, pp. 5091–95. Pubmed, doi:10.1073/pnas.74.11.5091.
Petes TD, Botstein D. Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5091–5095.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 1977

Volume

74

Issue

11

Start / End Page

5091 / 5095

Location

United States

Related Subject Headings

  • Spores, Fungal
  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Nucleic Acid Hybridization
  • Mitosis
  • DNA
  • Chromosomes
  • Base Sequence