Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel

Nitric oxide and cerebral blood flow responses to hyperbaric oxygen.

Publication ,  Journal Article
Demchenko, IT; Boso, AE; O'Neill, TJ; Bennett, PB; Piantadosi, CA
Published in: J Appl Physiol (1985)
April 2000

We have tested the hypothesis that cerebral nitric oxide (NO) production is involved in hyperbaric O(2) (HBO(2)) neurotoxicity. Regional cerebral blood flow (rCBF) and electroencephalogram (EEG) were measured in anesthetized rats during O(2) exposure to 1, 3, 4, and 5 ATA with or without administration of the NO synthase inhibitor (N(omega)-nitro-L-arginine methyl ester), L-arginine, NO donors, or the N-methyl-D-aspartate receptor inhibitor MK-801. After 30 min of O(2) exposure at 3 and 4 ATA, rCBF decreased by 26-39% and by 37-43%, respectively, and was sustained for 75 min. At 5 ATA, rCBF decreased over 30 min in the substantia nigra by one-third but, thereafter, gradually returned to preexposure levels, preceding the onset of EEG spiking activity. Rats pretreated with N(omega)-nitro-L-arginine methyl ester and exposed to HBO(2) at 5 ATA maintained a low rCBF. MK-801 did not alter the cerebrovascular responses to HBO(2) at 5 ATA but prevented the EEG spikes. NO donors increased rCBF in control rats but were ineffective during HBO(2) exposures. The data provide evidence that relative lack of NO activity contributes to decreased rCBF under HBO(2), but, as exposure time is prolonged, NO production increases and augments rCBF in anticipation of neuronal excitation.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

April 2000

Volume

88

Issue

4

Start / End Page

1381 / 1389

Location

United States

Related Subject Headings

  • Regional Blood Flow
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Nitric Oxide Donors
  • Nitric Oxide
  • NG-Nitroarginine Methyl Ester
  • Hyperbaric Oxygenation
  • Electroencephalography
  • Dizocilpine Maleate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Demchenko, I. T., Boso, A. E., O’Neill, T. J., Bennett, P. B., & Piantadosi, C. A. (2000). Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. J Appl Physiol (1985), 88(4), 1381–1389. https://doi.org/10.1152/jappl.2000.88.4.1381
Demchenko, I. T., A. E. Boso, T. J. O’Neill, P. B. Bennett, and C. A. Piantadosi. “Nitric oxide and cerebral blood flow responses to hyperbaric oxygen.J Appl Physiol (1985) 88, no. 4 (April 2000): 1381–89. https://doi.org/10.1152/jappl.2000.88.4.1381.
Demchenko IT, Boso AE, O’Neill TJ, Bennett PB, Piantadosi CA. Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. J Appl Physiol (1985). 2000 Apr;88(4):1381–9.
Demchenko, I. T., et al. “Nitric oxide and cerebral blood flow responses to hyperbaric oxygen.J Appl Physiol (1985), vol. 88, no. 4, Apr. 2000, pp. 1381–89. Pubmed, doi:10.1152/jappl.2000.88.4.1381.
Demchenko IT, Boso AE, O’Neill TJ, Bennett PB, Piantadosi CA. Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. J Appl Physiol (1985). 2000 Apr;88(4):1381–1389.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

April 2000

Volume

88

Issue

4

Start / End Page

1381 / 1389

Location

United States

Related Subject Headings

  • Regional Blood Flow
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Nitric Oxide Donors
  • Nitric Oxide
  • NG-Nitroarginine Methyl Ester
  • Hyperbaric Oxygenation
  • Electroencephalography
  • Dizocilpine Maleate