Rat myoblast fusion requires metalloendoprotease activity.
Publication
, Journal Article
Couch, CB; Strittmatter, WJ
Published in: Cell
January 1983
The calcium-dependent fusion of cultured rat myoblasts to multinucleate myotubes appears to require the activity of a neutral metalloendoprotease at the time of fusion. Metalloendoprotease inhibitors and synthetic dipeptide substrates prevent myoblast fusion when added to fusion-competent myoblasts with the addition of calcium. Metalloendoprotease activity has been identified and partially characterized in myoblast membranes with a fluorogenic protease substrate, and is inhibited by the same compounds that prevent fusion.
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Published In
Cell
DOI
ISSN
0092-8674
Publication Date
January 1983
Volume
32
Issue
1
Start / End Page
257 / 265
Location
United States
Related Subject Headings
- Rats
- Protease Inhibitors
- Muscles
- Metalloendopeptidases
- Developmental Biology
- Cells, Cultured
- Cell Fusion
- Animals
- 32 Biomedical and clinical sciences
- 31 Biological sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Couch, C. B., & Strittmatter, W. J. (1983). Rat myoblast fusion requires metalloendoprotease activity. Cell, 32(1), 257–265. https://doi.org/10.1016/0092-8674(83)90516-0
Couch, C. B., and W. J. Strittmatter. “Rat myoblast fusion requires metalloendoprotease activity.” Cell 32, no. 1 (January 1983): 257–65. https://doi.org/10.1016/0092-8674(83)90516-0.
Couch CB, Strittmatter WJ. Rat myoblast fusion requires metalloendoprotease activity. Cell. 1983 Jan;32(1):257–65.
Couch, C. B., and W. J. Strittmatter. “Rat myoblast fusion requires metalloendoprotease activity.” Cell, vol. 32, no. 1, Jan. 1983, pp. 257–65. Pubmed, doi:10.1016/0092-8674(83)90516-0.
Couch CB, Strittmatter WJ. Rat myoblast fusion requires metalloendoprotease activity. Cell. 1983 Jan;32(1):257–265.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
January 1983
Volume
32
Issue
1
Start / End Page
257 / 265
Location
United States
Related Subject Headings
- Rats
- Protease Inhibitors
- Muscles
- Metalloendopeptidases
- Developmental Biology
- Cells, Cultured
- Cell Fusion
- Animals
- 32 Biomedical and clinical sciences
- 31 Biological sciences