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The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.

Publication ,  Journal Article
Clift, RA; Buckner, CD; Thomas, ED; Kopecky, KJ; Appelbaum, FR; Tallman, M; Storb, R; Sanders, J; Sullivan, K; Banaji, M
Published in: Bone Marrow Transplant
October 1987

The results are presented of allogeneic transplantation for 363 patients with acute non-lymphoblastic leukemia treated in Seattle from May 1973 through December 1985. The probabilities of surviving disease-free for 5 years for patients transplanted in first remission, in second remission, in untreated first relapse or in chemotherapy-resistant first relapse were 46%, 28%, 30%, and 21%, respectively. The corresponding probabilities of relapse within 5 years were 25%, 37%, 36% and 56%, respectively. Prognostic factors predictive of survival after marrow transplantation for patients transplanted in first remission included age, donor sex and the number of circulating blasts at the time of diagnosis. Acute graft-versus-host disease (GVHD) had a major adverse effect on survival, but chronic GVHD decreased the risk of relapse for patients transplanted in first remission.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

October 1987

Volume

2

Issue

3

Start / End Page

243 / 258

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Bone Marrow Transplantation
 

Citation

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Chicago
ICMJE
MLA
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Clift, R. A., Buckner, C. D., Thomas, E. D., Kopecky, K. J., Appelbaum, F. R., Tallman, M., … Banaji, M. (1987). The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation. Bone Marrow Transplant, 2(3), 243–258.
Clift, R. A., C. D. Buckner, E. D. Thomas, K. J. Kopecky, F. R. Appelbaum, M. Tallman, R. Storb, J. Sanders, K. Sullivan, and M. Banaji. “The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.Bone Marrow Transplant 2, no. 3 (October 1987): 243–58.
Clift RA, Buckner CD, Thomas ED, Kopecky KJ, Appelbaum FR, Tallman M, et al. The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation. Bone Marrow Transplant. 1987 Oct;2(3):243–58.
Clift, R. A., et al. “The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.Bone Marrow Transplant, vol. 2, no. 3, Oct. 1987, pp. 243–58.
Clift RA, Buckner CD, Thomas ED, Kopecky KJ, Appelbaum FR, Tallman M, Storb R, Sanders J, Sullivan K, Banaji M. The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation. Bone Marrow Transplant. 1987 Oct;2(3):243–258.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

October 1987

Volume

2

Issue

3

Start / End Page

243 / 258

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Bone Marrow Transplantation