Skip to main content

Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission.

Publication ,  Journal Article
Doney, K; Buckner, CD; Kopecky, KJ; Sanders, JE; Appelbaum, FR; Clift, R; Sullivan, K; Witherspoon, R; Storb, R; Thomas, ED
Published in: Bone Marrow Transplant
December 1987

Forty-six patients with acute lymphoblastic leukemia (ALL) in first marrow remission underwent allogeneic marrow transplantation between August 1976 and June 1985. Thirty-four patients had no extramedullary disease after remission induction and 12 had extramedullary relapses prior to or at the time of marrow grafting. The conditioning regimen included cyclophosphamide followed by total body irradiation, 9.2-15.75 Gy, administered as a single dose or in six or seven daily fractions. Marrow donors were genotypically HLA-identical siblings. Methotrexate was given as prophylaxis for graft-versus-host disease (GVHD). Forty-four patients had marrow engraftment. The incidence of grades II-IV acute GVHD was 52%. Clinical chronic GVHD occurred in 21 patients. Eighteen patients are alive 1-9 years (median = 4.2 years) after marrow grafting, 15 of whom are in continuous complete remission. The estimated probability of relapse within 2 years (+/- standard error) is 41 +/- 9% and the probability of relapse-free survival at 5 years is 28 +/- 7%. Major causes of death were recurrent leukemia, acute GVHD and interstitial pneumonia. Actuarial probabilities of survival, relapse and disease-free survival were not significantly different between those patients who did and those who did not have extramedullary disease after attaining first marrow remission.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

December 1987

Volume

2

Issue

4

Start / End Page

355 / 363

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Time Factors
  • Prognosis
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Bone Marrow Transplantation
  • 3211 Oncology and carcinogenesis
  • 3201 Cardiovascular medicine and haematology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Doney, K., Buckner, C. D., Kopecky, K. J., Sanders, J. E., Appelbaum, F. R., Clift, R., … Thomas, E. D. (1987). Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission. Bone Marrow Transplant, 2(4), 355–363.
Doney, K., C. D. Buckner, K. J. Kopecky, J. E. Sanders, F. R. Appelbaum, R. Clift, K. Sullivan, R. Witherspoon, R. Storb, and E. D. Thomas. “Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission.Bone Marrow Transplant 2, no. 4 (December 1987): 355–63.
Doney K, Buckner CD, Kopecky KJ, Sanders JE, Appelbaum FR, Clift R, et al. Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission. Bone Marrow Transplant. 1987 Dec;2(4):355–63.
Doney, K., et al. “Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission.Bone Marrow Transplant, vol. 2, no. 4, Dec. 1987, pp. 355–63.
Doney K, Buckner CD, Kopecky KJ, Sanders JE, Appelbaum FR, Clift R, Sullivan K, Witherspoon R, Storb R, Thomas ED. Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission. Bone Marrow Transplant. 1987 Dec;2(4):355–363.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

December 1987

Volume

2

Issue

4

Start / End Page

355 / 363

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Time Factors
  • Prognosis
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Bone Marrow Transplantation
  • 3211 Oncology and carcinogenesis
  • 3201 Cardiovascular medicine and haematology
  • 1112 Oncology and Carcinogenesis