Skip to main content

Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease.

Publication ,  Journal Article
Bolger, GB; Sullivan, KM; Spence, AM; Appelbaum, FR; Johnston, R; Sanders, JE; Deeg, HJ; Witherspoon, RP; Doney, KC; Nims, J
Published in: Neurology
August 1986

Three patients with chronic graft-versus-host disease (GVHD) developed myasthenia gravis (MG) 762 to 1,180 days after allogeneic bone marrow transplantation. Symptoms of MG were observed after taper or discontinuation of immunosuppressive treatment of chronic GVHD. All patients developed antibodies to acetylcholine receptor, and one had antibody formation to striated muscle. One patient died of complications of treatment of MG. The severity of disease underscores the importance of the differential diagnosis and the need for prompt therapy of this late complication after human bone marrow transplantation.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

August 1986

Volume

36

Issue

8

Start / End Page

1087 / 1091

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Neurology & Neurosurgery
  • Myasthenia Gravis
  • Humans
  • Graft vs Host Disease
  • Female
  • Child
  • Bone Marrow Transplantation
  • Autoantibodies
  • Antibodies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bolger, G. B., Sullivan, K. M., Spence, A. M., Appelbaum, F. R., Johnston, R., Sanders, J. E., … Nims, J. (1986). Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease. Neurology, 36(8), 1087–1091. https://doi.org/10.1212/wnl.36.8.1087
Bolger, G. B., K. M. Sullivan, A. M. Spence, F. R. Appelbaum, R. Johnston, J. E. Sanders, H. J. Deeg, R. P. Witherspoon, K. C. Doney, and J. Nims. “Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease.Neurology 36, no. 8 (August 1986): 1087–91. https://doi.org/10.1212/wnl.36.8.1087.
Bolger GB, Sullivan KM, Spence AM, Appelbaum FR, Johnston R, Sanders JE, et al. Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease. Neurology. 1986 Aug;36(8):1087–91.
Bolger, G. B., et al. “Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease.Neurology, vol. 36, no. 8, Aug. 1986, pp. 1087–91. Pubmed, doi:10.1212/wnl.36.8.1087.
Bolger GB, Sullivan KM, Spence AM, Appelbaum FR, Johnston R, Sanders JE, Deeg HJ, Witherspoon RP, Doney KC, Nims J. Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease. Neurology. 1986 Aug;36(8):1087–1091.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

August 1986

Volume

36

Issue

8

Start / End Page

1087 / 1091

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Neurology & Neurosurgery
  • Myasthenia Gravis
  • Humans
  • Graft vs Host Disease
  • Female
  • Child
  • Bone Marrow Transplantation
  • Autoantibodies
  • Antibodies