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Central neurotoxicity after exposure to organic lead: susceptibility to seizures.

Publication ,  Journal Article
Swartzwelder, HS
Published in: Neurosci Lett
July 31, 1985

Organic leads are present in the environment from a variety of sources and produce metabolites such as triethyl lead (TEL) which have relatively long half-lives in the brain. However, little is known at present about the possible neurological consequences of exposure to these compounds. The susceptibility of an animal to experimentally induced seizures has been used as a reliable index of neural function to assess neurotoxic insult, and the present study assessed the effect of TEL upon this index. Adult male rats of the Fischer-344 strain were divided into groups and treated with 7.88 mg/kg of TEL or the control vehicle at 1, 7, 14 or 28 days prior to a single challenge with 35 mg/kg of pentylenetetrazole (PTZ). The rats treated with TEL were more susceptible to PTZ-induced seizures than were the controls. This effect was statistically significant on days 7, 14 and 28 after treatment, although some elevation of seizure scores was observed among TEL-treated animals on day 1. These results demonstrate a functional change in the central nervous system after exposure to TEL, which persists for at least 4 weeks after exposure.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 31, 1985

Volume

58

Issue

2

Start / End Page

225 / 228

Location

Ireland

Related Subject Headings

  • Tetraethyl Lead
  • Seizures
  • Rats, Inbred F344
  • Rats
  • Pentylenetetrazole
  • Organometallic Compounds
  • Male
  • Limbic System
  • Drug Interactions
  • Brain Diseases
 

Citation

APA
Chicago
ICMJE
MLA
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Swartzwelder, H. S. (1985). Central neurotoxicity after exposure to organic lead: susceptibility to seizures. Neurosci Lett, 58(2), 225–228. https://doi.org/10.1016/0304-3940(85)90168-5
Swartzwelder, H. S. “Central neurotoxicity after exposure to organic lead: susceptibility to seizures.Neurosci Lett 58, no. 2 (July 31, 1985): 225–28. https://doi.org/10.1016/0304-3940(85)90168-5.
Swartzwelder HS. Central neurotoxicity after exposure to organic lead: susceptibility to seizures. Neurosci Lett. 1985 Jul 31;58(2):225–8.
Swartzwelder, H. S. “Central neurotoxicity after exposure to organic lead: susceptibility to seizures.Neurosci Lett, vol. 58, no. 2, July 1985, pp. 225–28. Pubmed, doi:10.1016/0304-3940(85)90168-5.
Swartzwelder HS. Central neurotoxicity after exposure to organic lead: susceptibility to seizures. Neurosci Lett. 1985 Jul 31;58(2):225–228.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 31, 1985

Volume

58

Issue

2

Start / End Page

225 / 228

Location

Ireland

Related Subject Headings

  • Tetraethyl Lead
  • Seizures
  • Rats, Inbred F344
  • Rats
  • Pentylenetetrazole
  • Organometallic Compounds
  • Male
  • Limbic System
  • Drug Interactions
  • Brain Diseases