Integrated circuit microchip system with multiplex capillary electrophoresis module for DNA analysis
In this paper, we describe the use of an integrated circuit (IC) microchip system as a detector in multiplex capillary electrophoresis (CE). This combination of multiplex capillary gel electrophoresis and the IC microchip technology represents a novel approach to DNA analysis on the microchip platform. Separation of DNA ladders using a multiplex CE microsystem of four capillaries was monitored simultaneously using the IC microchip system. The IC microchip-CE system has advantages such as low cost, rapid analysis, compactness, and multiplex capability, and has great potential as an alternative system to conventional capillary array gel electrophoresis systems based on charge-coupled device (CCD) detection. © 2002 Elsevier Science B.V. All rights reserved.
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- Analytical Chemistry
- 4018 Nanotechnology
- 4004 Chemical engineering
- 3401 Analytical chemistry
- 0399 Other Chemical Sciences
- 0301 Analytical Chemistry
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Analytical Chemistry
- 4018 Nanotechnology
- 4004 Chemical engineering
- 3401 Analytical chemistry
- 0399 Other Chemical Sciences
- 0301 Analytical Chemistry