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In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices.

Publication ,  Journal Article
Vo-Dinh, T; Panjehpour, M; Overholt, BF; Farris, C; Buckley, FP; Sneed, R
Published in: Lasers in surgery and medicine
January 1995

We report the use of new diagnostic parameters based on the differential normalized fluorescence (DNF) signals for malignant tumor diagnosis.Over 200 measurements of endogenous fluorescence from normal and malignant esophageal tissues were performed during routine endoscopy in 48 patients. A pulsed nitrogen-pumped dye laser was used to provide in situ excitation at 410 nm. Direct collection of the fluorescence signal emitted by the tissue was achieved using an intensified photodiode array detector equipped with a fiberoptic probe.The fluorescence signals were normalized with respect to the total fluorescence signal area. The cancer diagnosis indices were defined by the difference between the normalized fluorescence signal of a tumor and the mean value of a reference set of normal tissues. The results of the DNF approach were compared with endoscopic examinations and histopathology interpretations of the biopsy samples. Excellent correlation in the classification of normal and malignant tumors for the samples was found.The data indicated that the DNF approach has a significant potential to provide a direct, real-time, and in-situ technique for cancer diagnosis of the esophagus without requiring biopsy of the tumors and time-consuming histopathology tests.

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Published In

Lasers in surgery and medicine

DOI

EISSN

1096-9101

ISSN

0196-8092

Publication Date

January 1995

Volume

16

Issue

1

Start / End Page

41 / 47

Related Subject Headings

  • Lasers
  • Humans
  • Fluorescence
  • Esophagus
  • Esophagoscopy
  • Esophageal Neoplasms
  • Dermatology & Venereal Diseases
  • Carcinoma, Squamous Cell
  • Adenocarcinoma
  • 3203 Dentistry
 

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Vo-Dinh, T., Panjehpour, M., Overholt, B. F., Farris, C., Buckley, F. P., & Sneed, R. (1995). In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices. Lasers in Surgery and Medicine, 16(1), 41–47. https://doi.org/10.1002/lsm.1900160106
Vo-Dinh, T., M. Panjehpour, B. F. Overholt, C. Farris, F. P. Buckley, and R. Sneed. “In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices.Lasers in Surgery and Medicine 16, no. 1 (January 1995): 41–47. https://doi.org/10.1002/lsm.1900160106.
Vo-Dinh T, Panjehpour M, Overholt BF, Farris C, Buckley FP, Sneed R. In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices. Lasers in surgery and medicine. 1995 Jan;16(1):41–7.
Vo-Dinh, T., et al. “In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices.Lasers in Surgery and Medicine, vol. 16, no. 1, Jan. 1995, pp. 41–47. Epmc, doi:10.1002/lsm.1900160106.
Vo-Dinh T, Panjehpour M, Overholt BF, Farris C, Buckley FP, Sneed R. In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices. Lasers in surgery and medicine. 1995 Jan;16(1):41–47.
Journal cover image

Published In

Lasers in surgery and medicine

DOI

EISSN

1096-9101

ISSN

0196-8092

Publication Date

January 1995

Volume

16

Issue

1

Start / End Page

41 / 47

Related Subject Headings

  • Lasers
  • Humans
  • Fluorescence
  • Esophagus
  • Esophagoscopy
  • Esophageal Neoplasms
  • Dermatology & Venereal Diseases
  • Carcinoma, Squamous Cell
  • Adenocarcinoma
  • 3203 Dentistry