Skip to main content
Journal cover image

Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma.

Publication ,  Journal Article
Willett, CG; Suit, HD; Tepper, JE; Mankin, HJ; Convery, K; Rosenberg, AL; Wood, WC
Published in: Cancer
July 15, 1991

From December 1981 to December 1989, 20 patients with primary or recurrent retroperitoneal sarcoma received 4000 to 5000 cGy of external beam radiation therapy (EBRT) in conjunction with surgical resection and intraoperative radiation therapy (IORT). Seventeen of 20 patients underwent complete (14 patients) or partial (3 patients) resection. Three patients had shown evidence of metastases after EBRT by the time of surgery. The 4-year actuarial local control and disease-free survival rates of the 17 patients undergoing resection were 81% and 64%, respectively. Twelve patients received IORT at the time of resection for microscopic disease (10 patients) or gross residual sarcoma (2 patients). Of the ten patients receiving IORT for microscopic tumor, one patient has died of local failure and peritoneal sarcomatosis and two patients have died of distant metastases only. The remaining seven patients are disease-free. One patient treated for gross residual sarcoma has experienced a local failure 1 year after IORT and is without disease 7 years after salvage chemotherapy. The other patient treated for gross residual sarcoma has died of local failure. Five patients did not receive IORT at the time of resection because of the extensive size of the tumor bed. Three of these patients are disease-free with one patient alive with lung metastases and one patient dying of hepatic metastases. Aggressive radiation and surgical procedures appear to provide satisfactory resectability and local control with acceptable tolerance.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

July 15, 1991

Volume

68

Issue

2

Start / End Page

278 / 283

Location

United States

Related Subject Headings

  • Survival Rate
  • Soft Tissue Neoplasms
  • Sarcoma
  • Retroperitoneal Neoplasms
  • Radiotherapy, High-Energy
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Willett, C. G., Suit, H. D., Tepper, J. E., Mankin, H. J., Convery, K., Rosenberg, A. L., & Wood, W. C. (1991). Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma. Cancer, 68(2), 278–283. https://doi.org/10.1002/1097-0142(19910715)68:2<278::aid-cncr2820680211>3.0.co;2-c
Willett, C. G., H. D. Suit, J. E. Tepper, H. J. Mankin, K. Convery, A. L. Rosenberg, and W. C. Wood. “Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma.Cancer 68, no. 2 (July 15, 1991): 278–83. https://doi.org/10.1002/1097-0142(19910715)68:2<278::aid-cncr2820680211>3.0.co;2-c.
Willett CG, Suit HD, Tepper JE, Mankin HJ, Convery K, Rosenberg AL, et al. Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma. Cancer. 1991 Jul 15;68(2):278–83.
Willett, C. G., et al. “Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma.Cancer, vol. 68, no. 2, July 1991, pp. 278–83. Pubmed, doi:10.1002/1097-0142(19910715)68:2<278::aid-cncr2820680211>3.0.co;2-c.
Willett CG, Suit HD, Tepper JE, Mankin HJ, Convery K, Rosenberg AL, Wood WC. Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma. Cancer. 1991 Jul 15;68(2):278–283.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

July 15, 1991

Volume

68

Issue

2

Start / End Page

278 / 283

Location

United States

Related Subject Headings

  • Survival Rate
  • Soft Tissue Neoplasms
  • Sarcoma
  • Retroperitoneal Neoplasms
  • Radiotherapy, High-Energy
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms