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Emerging therapeutic targets and agents for glioblastoma migrating cells.

Publication ,  Journal Article
Di, C; Mattox, AK; Harward, S; Adamson, C
Published in: Anticancer Agents Med Chem
September 2010

Glioblastoma multiforme (GBM) is one of the most common and most aggressive types of primary brain tumors in humans. Even with aggressive surgical resections using state of the art preoperative and intraoperative neuroim-aging, along with the most recent techniques in radiotherapy and chemotherapy, the prognosis for GBM patients remains dismal. Survival after diagnosis is about 12-14 months. The tumor cells which already have migrated into normal brain tissue beyond the surgical resection margin account for the inability to effectively treat this tumor. Understanding how to control the migration of GBM cells is paramount to future therapies. In this review, we will focus on the emerging targets and agents which are being exploited to inhibit the migration of glioma cells in GBM.

Duke Scholars

Published In

Anticancer Agents Med Chem

DOI

EISSN

1875-5992

Publication Date

September 2010

Volume

10

Issue

7

Start / End Page

543 / 555

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Receptors, Transforming Growth Factor beta
  • Prognosis
  • Neoplastic Stem Cells
  • Molecular Targeted Therapy
  • Medicinal & Biomolecular Chemistry
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Glioblastoma
 

Citation

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Di, C., Mattox, A. K., Harward, S., & Adamson, C. (2010). Emerging therapeutic targets and agents for glioblastoma migrating cells. Anticancer Agents Med Chem, 10(7), 543–555. https://doi.org/10.2174/187152010793498618
Di, Chunhui, Austin K. Mattox, Steve Harward, and Cory Adamson. “Emerging therapeutic targets and agents for glioblastoma migrating cells.Anticancer Agents Med Chem 10, no. 7 (September 2010): 543–55. https://doi.org/10.2174/187152010793498618.
Di C, Mattox AK, Harward S, Adamson C. Emerging therapeutic targets and agents for glioblastoma migrating cells. Anticancer Agents Med Chem. 2010 Sep;10(7):543–55.
Di, Chunhui, et al. “Emerging therapeutic targets and agents for glioblastoma migrating cells.Anticancer Agents Med Chem, vol. 10, no. 7, Sept. 2010, pp. 543–55. Pubmed, doi:10.2174/187152010793498618.
Di C, Mattox AK, Harward S, Adamson C. Emerging therapeutic targets and agents for glioblastoma migrating cells. Anticancer Agents Med Chem. 2010 Sep;10(7):543–555.

Published In

Anticancer Agents Med Chem

DOI

EISSN

1875-5992

Publication Date

September 2010

Volume

10

Issue

7

Start / End Page

543 / 555

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Receptors, Transforming Growth Factor beta
  • Prognosis
  • Neoplastic Stem Cells
  • Molecular Targeted Therapy
  • Medicinal & Biomolecular Chemistry
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Glioblastoma