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American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer.

Publication ,  Journal Article
Rizzo, JD; Brouwers, M; Hurley, P; Seidenfeld, J; Arcasoy, MO; Spivak, JL; Bennett, CL; Bohlius, J; Evanchuk, D; Goode, MJ; Jakubowski, AA ...
Published in: J Clin Oncol
November 20, 2010

PURPOSE: To update American Society of Clinical Oncology/American Society of Hematology recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS: An Update Committee reviewed data published between January 2007 and January 2010. MEDLINE and the Cochrane Library were searched. RESULTS: The literature search yielded one new individual patient data analysis and four literature-based meta-analyses, two systematic reviews, and 13 publications reporting new results from randomized controlled trials not included in prior or new reviews. RECOMMENDATIONS: For patients undergoing myelosuppressive chemotherapy who have a hemoglobin (Hb) level less than 10 g/dL, the Update Committee recommends that clinicians discuss potential harms (eg, thromboembolism, shorter survival) and benefits (eg, decreased transfusions) of ESAs and compare these with potential harms (eg, serious infections, immune-mediated adverse reactions) and benefits (eg, rapid Hb improvement) of RBC transfusions. Individual preferences for assumed risk should contribute to shared decisions on managing chemotherapy-induced anemia. The Committee cautions against ESA use under other circumstances. If used, ESAs should be administered at the lowest dose possible and should increase Hb to the lowest concentration possible to avoid transfusions. Available evidence does not identify Hb levels ≥ 10 g/dL either as thresholds for initiating treatment or as targets for ESA therapy. Starting doses and dose modifications after response or nonresponse should follow US Food and Drug Administration-approved labeling. ESAs should be discontinued after 6 to 8 weeks in nonresponders. ESAs should be avoided in patients with cancer not receiving concurrent chemotherapy, except for those with lower risk myelodysplastic syndromes. Caution should be exercised when using ESAs with chemotherapeutic agents in diseases associated with increased risk of thromboembolic complications. Table 1 lists detailed recommendations.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

November 20, 2010

Volume

28

Issue

33

Start / End Page

4996 / 5010

Location

United States

Related Subject Headings

  • Recombinant Proteins
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Hematinics
  • Erythropoietin
  • Disease Progression
  • Darbepoetin alfa
  • Anemia
  • Adult
 

Citation

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Rizzo, J. D., Brouwers, M., Hurley, P., Seidenfeld, J., Arcasoy, M. O., Spivak, J. L., … American Society of Hematology, . (2010). American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer. J Clin Oncol, 28(33), 4996–5010. https://doi.org/10.1200/JCO.2010.29.2201
Rizzo, J Douglas, Melissa Brouwers, Patricia Hurley, Jerome Seidenfeld, Murat O. Arcasoy, Jerry L. Spivak, Charles L. Bennett, et al. “American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer.J Clin Oncol 28, no. 33 (November 20, 2010): 4996–5010. https://doi.org/10.1200/JCO.2010.29.2201.
Rizzo JD, Brouwers M, Hurley P, Seidenfeld J, Arcasoy MO, Spivak JL, et al. American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer. J Clin Oncol. 2010 Nov 20;28(33):4996–5010.
Rizzo, J. Douglas, et al. “American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer.J Clin Oncol, vol. 28, no. 33, Nov. 2010, pp. 4996–5010. Pubmed, doi:10.1200/JCO.2010.29.2201.
Rizzo JD, Brouwers M, Hurley P, Seidenfeld J, Arcasoy MO, Spivak JL, Bennett CL, Bohlius J, Evanchuk D, Goode MJ, Jakubowski AA, Regan DH, Somerfield MR, American Society of Clinical Oncology, American Society of Hematology. American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer. J Clin Oncol. 2010 Nov 20;28(33):4996–5010.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

November 20, 2010

Volume

28

Issue

33

Start / End Page

4996 / 5010

Location

United States

Related Subject Headings

  • Recombinant Proteins
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Hematinics
  • Erythropoietin
  • Disease Progression
  • Darbepoetin alfa
  • Anemia
  • Adult