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Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway.

Publication ,  Journal Article
Fu, P; Jiang, X; Arcasoy, MO
Published in: Biochem Biophys Res Commun
February 13, 2009

The role of erythropoietin receptor (EpoR) expression in tumor cells and the potential of EpoR-mediated signaling to contribute to cellular proliferation and invasiveness require further characterization. To determine whether EpoR expression and activation in tumor cells modulates intracellular signal transduction to promote cellular proliferation and migration, we employed a novel experimental model using human breast cancer cells engineered to stably express a constitutively active EpoR-R129C variant. EpoR-R129C expression resulted in increased cellular proliferation and migration of breast cancer cells and these effects were associated with significantly increased Epo-induced phosphorylation of ERK1/2, AKT and c-Jun-NH2-kinase (SAPK/JNK) proteins. Expression of the constitutively active EpoR-R129C receptor promoted the proliferation and migration of breast cancer cells via activation of ERK- and SAPK/JNK-dependent signaling pathways, respectively. These findings suggest that EpoR over-expression and activation in breast cancer cells has the potential to contribute to tumor progression by promoting the proliferation and invasiveness of the neoplastic cells.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

EISSN

1090-2104

Publication Date

February 13, 2009

Volume

379

Issue

3

Start / End Page

696 / 701

Location

United States

Related Subject Headings

  • Receptors, Erythropoietin
  • Neoplasm Invasiveness
  • Mitogen-Activated Protein Kinases
  • Humans
  • Cell Proliferation
  • Cell Movement
  • Cell Line, Tumor
  • Breast Neoplasms
  • Biochemistry & Molecular Biology
  • 3404 Medicinal and biomolecular chemistry
 

Citation

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Fu, P., Jiang, X., & Arcasoy, M. O. (2009). Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway. Biochem Biophys Res Commun, 379(3), 696–701. https://doi.org/10.1016/j.bbrc.2008.12.146
Fu, Ping, Xiaohong Jiang, and Murat O. Arcasoy. “Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway.Biochem Biophys Res Commun 379, no. 3 (February 13, 2009): 696–701. https://doi.org/10.1016/j.bbrc.2008.12.146.
Fu, Ping, et al. “Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway.Biochem Biophys Res Commun, vol. 379, no. 3, Feb. 2009, pp. 696–701. Pubmed, doi:10.1016/j.bbrc.2008.12.146.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

EISSN

1090-2104

Publication Date

February 13, 2009

Volume

379

Issue

3

Start / End Page

696 / 701

Location

United States

Related Subject Headings

  • Receptors, Erythropoietin
  • Neoplasm Invasiveness
  • Mitogen-Activated Protein Kinases
  • Humans
  • Cell Proliferation
  • Cell Movement
  • Cell Line, Tumor
  • Breast Neoplasms
  • Biochemistry & Molecular Biology
  • 3404 Medicinal and biomolecular chemistry