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Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.

Publication ,  Journal Article
Cohen, OJ; Pantaleo, G; Holodniy, M; Fox, CH; Orenstein, JM; Schnittman, S; Niu, M; Graziosi, C; Pavlakis, GN; Lalezari, J; Bartlett, JA ...
Published in: J Infect Dis
April 1996

Initiation of antiretroviral monotherapy early in the course of infection with human immunodeficiency virus may result in a temporary slowing in the rate of disease progression; however, little is known about the virologic effects of early therapy. Virus load was measured in peripheral blood and lymph nodes from 16 antiretroviral-naive patients with a mean CD4 T lymphocyte count of 659 cells/microliter at baseline and after 8 weeks of either no treatment or zidovudine therapy. CD4 T lymphocyte counts and all virologic parameters examined remained unchanged regardless of zidovudine treatment status. Histopathology and virus distribution within lymph nodes remained constant between baseline and week 8 in each patient, indicating that the virologic and histologic parameters examined in a single lymph node are representative of a systemic process. Early antiretroviral monotherapy with zidovudine had no effect on virologic parameters in this group of patients with relatively high CD4 T lymphocyte counts and low measures of virus load at baseline.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

April 1996

Volume

173

Issue

4

Start / End Page

849 / 856

Location

United States

Related Subject Headings

  • Zidovudine
  • Virus Replication
  • Time Factors
  • Reverse Transcriptase Inhibitors
  • RNA-Directed DNA Polymerase
  • Molecular Sequence Data
  • Microbiology
  • Male
  • Lymph Nodes
  • In Situ Hybridization
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cohen, O. J., Pantaleo, G., Holodniy, M., Fox, C. H., Orenstein, J. M., Schnittman, S., … Fauci, A. S. (1996). Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. J Infect Dis, 173(4), 849–856. https://doi.org/10.1093/infdis/173.4.849
Cohen, O. J., G. Pantaleo, M. Holodniy, C. H. Fox, J. M. Orenstein, S. Schnittman, M. Niu, et al. “Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.J Infect Dis 173, no. 4 (April 1996): 849–56. https://doi.org/10.1093/infdis/173.4.849.
Cohen OJ, Pantaleo G, Holodniy M, Fox CH, Orenstein JM, Schnittman S, et al. Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. J Infect Dis. 1996 Apr;173(4):849–56.
Cohen, O. J., et al. “Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.J Infect Dis, vol. 173, no. 4, Apr. 1996, pp. 849–56. Pubmed, doi:10.1093/infdis/173.4.849.
Cohen OJ, Pantaleo G, Holodniy M, Fox CH, Orenstein JM, Schnittman S, Niu M, Graziosi C, Pavlakis GN, Lalezari J, Bartlett JA, Steigbigel RT, Cohn J, Novak R, McMahon D, Bilello J, Fauci AS. Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. J Infect Dis. 1996 Apr;173(4):849–856.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

April 1996

Volume

173

Issue

4

Start / End Page

849 / 856

Location

United States

Related Subject Headings

  • Zidovudine
  • Virus Replication
  • Time Factors
  • Reverse Transcriptase Inhibitors
  • RNA-Directed DNA Polymerase
  • Molecular Sequence Data
  • Microbiology
  • Male
  • Lymph Nodes
  • In Situ Hybridization