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Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.

Publication ,  Journal Article
Williams, MS; Weiss, EJ; Sabatine, MS; Simon, DI; Bahou, WF; Becker, LC; Parise, LV; Dauerman, HL; French, PA; Smyth, SS; Becker, RC ...
Published in: Arterioscler Thromb Vasc Biol
December 2010

Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.

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Published In

Arterioscler Thromb Vasc Biol

DOI

EISSN

1524-4636

Publication Date

December 2010

Volume

30

Issue

12

Start / End Page

2372 / 2384

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Platelet Membrane Glycoproteins
  • Platelet Aggregation Inhibitors
  • Phenotype
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Drug Resistance
 

Citation

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Williams, M. S., Weiss, E. J., Sabatine, M. S., Simon, D. I., Bahou, W. F., Becker, L. C., … 2010 Platelet Colloquium Participants, . (2010). Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arterioscler Thromb Vasc Biol, 30(12), 2372–2384. https://doi.org/10.1161/ATVBAHA.110.218131
Williams, Marlene S., Ethan J. Weiss, Marc S. Sabatine, Daniel I. Simon, Wadie F. Bahou, Lewis C. Becker, Leslie V. Parise, et al. “Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.Arterioscler Thromb Vasc Biol 30, no. 12 (December 2010): 2372–84. https://doi.org/10.1161/ATVBAHA.110.218131.
Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, et al. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2372–84.
Williams, Marlene S., et al. “Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.Arterioscler Thromb Vasc Biol, vol. 30, no. 12, Dec. 2010, pp. 2372–84. Pubmed, doi:10.1161/ATVBAHA.110.218131.
Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC, 2010 Platelet Colloquium Participants. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2372–2384.

Published In

Arterioscler Thromb Vasc Biol

DOI

EISSN

1524-4636

Publication Date

December 2010

Volume

30

Issue

12

Start / End Page

2372 / 2384

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Platelet Membrane Glycoproteins
  • Platelet Aggregation Inhibitors
  • Phenotype
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Drug Resistance