Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.
Publication
, Journal Article
Benner, EJ; Mosley, RL; Destache, CJ; Lewis, TB; Jackson-Lewis, V; Gorantla, S; Nemachek, C; Green, SR; Przedborski, S; Gendelman, HE
Published in: Proc Natl Acad Sci U S A
June 22, 2004
Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
June 22, 2004
Volume
101
Issue
25
Start / End Page
9435 / 9440
Location
United States
Related Subject Headings
- Transcription, Genetic
- Substantia Nigra
- Reverse Transcriptase Polymerase Chain Reaction
- Parkinsonian Disorders
- Ovalbumin
- Neurons
- Mycobacterium tuberculosis
- Mice
- Mesencephalon
- Immunohistochemistry
Citation
APA
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ICMJE
MLA
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Benner, E. J., Mosley, R. L., Destache, C. J., Lewis, T. B., Jackson-Lewis, V., Gorantla, S., … Gendelman, H. E. (2004). Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A, 101(25), 9435–9440. https://doi.org/10.1073/pnas.0400569101
Benner, Eric J., R Lee Mosley, Chris J. Destache, Travis B. Lewis, Vernice Jackson-Lewis, Santhi Gorantla, Craig Nemachek, Steven R. Green, Serge Przedborski, and Howard E. Gendelman. “Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.” Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9435–40. https://doi.org/10.1073/pnas.0400569101.
Benner EJ, Mosley RL, Destache CJ, Lewis TB, Jackson-Lewis V, Gorantla S, et al. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9435–40.
Benner, Eric J., et al. “Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.” Proc Natl Acad Sci U S A, vol. 101, no. 25, June 2004, pp. 9435–40. Pubmed, doi:10.1073/pnas.0400569101.
Benner EJ, Mosley RL, Destache CJ, Lewis TB, Jackson-Lewis V, Gorantla S, Nemachek C, Green SR, Przedborski S, Gendelman HE. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9435–9440.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
June 22, 2004
Volume
101
Issue
25
Start / End Page
9435 / 9440
Location
United States
Related Subject Headings
- Transcription, Genetic
- Substantia Nigra
- Reverse Transcriptase Polymerase Chain Reaction
- Parkinsonian Disorders
- Ovalbumin
- Neurons
- Mycobacterium tuberculosis
- Mice
- Mesencephalon
- Immunohistochemistry