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Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile.

Publication ,  Journal Article
Verani, MS; Jeroudi, MO; Mahmarian, JJ; Boyce, TM; Borges-Neto, S; Patel, B; Bolli, R
Published in: J Am Coll Cardiol
December 1988

Myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile was investigated as a means to assess myocardial infarct size during coronary occlusion and to quantify the extent of salvaged myocardium after coronary occlusion followed by reperfusion. Open chest dogs underwent either a permanent coronary artery occlusion (Group 1, n = 16) or a 2 h occlusion followed by reperfusion (Group 2, n = 15). Animals in both groups were killed 48 h after occlusion. During coronary occlusion, 23 of the 25 dogs that survived the coronary occlusions had abnormal myocardial scintigrams. The scintigraphic perfusion defect size correlated well with the pathologic infarct size (r = 0.85 and 0.95 by planar and tomographic imaging, respectively). The planar scintigraphic defect size, but not the tomographic defect size, overestimated the pathologic size. The planar scintigraphic defect size observed during coronary occlusion was markedly reduced 48 h after reperfusion (24.8 +/- 12.8% to 10.6 +/- 9.7% of the left ventricle, p less than 0.003). The uptake of technetium-99m hexakis 2-methoxyisobutyl isonitrile in the ischemic myocardium increased significantly 48 h after reperfusion (p less than 0.003) and correlated with the increase in regional myocardial blood flow, as assessed by radioactive microspheres (r = 0.83, p less than 0.01). Thus, myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile allows reliable demonstration of the presence of acute infarction, estimation of infarct size and quantification of the extent of salvaged myocardium after coronary reperfusion.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

December 1988

Volume

12

Issue

6

Start / End Page

1573 / 1581

Location

United States

Related Subject Headings

  • Technetium Tc 99m Sestamibi
  • Radionuclide Imaging
  • Organometallic Compounds
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Male
  • Female
  • Dogs
  • Coronary Disease
  • Cardiovascular System & Hematology
 

Citation

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Verani, M. S., Jeroudi, M. O., Mahmarian, J. J., Boyce, T. M., Borges-Neto, S., Patel, B., & Bolli, R. (1988). Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile. J Am Coll Cardiol, 12(6), 1573–1581. https://doi.org/10.1016/s0735-1097(88)80028-7
Verani, M. S., M. O. Jeroudi, J. J. Mahmarian, T. M. Boyce, S. Borges-Neto, B. Patel, and R. Bolli. “Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile.J Am Coll Cardiol 12, no. 6 (December 1988): 1573–81. https://doi.org/10.1016/s0735-1097(88)80028-7.
Verani, M. S., et al. “Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile.J Am Coll Cardiol, vol. 12, no. 6, Dec. 1988, pp. 1573–81. Pubmed, doi:10.1016/s0735-1097(88)80028-7.
Verani MS, Jeroudi MO, Mahmarian JJ, Boyce TM, Borges-Neto S, Patel B, Bolli R. Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile. J Am Coll Cardiol. 1988 Dec;12(6):1573–1581.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

December 1988

Volume

12

Issue

6

Start / End Page

1573 / 1581

Location

United States

Related Subject Headings

  • Technetium Tc 99m Sestamibi
  • Radionuclide Imaging
  • Organometallic Compounds
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Male
  • Female
  • Dogs
  • Coronary Disease
  • Cardiovascular System & Hematology