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Thrombophilia in pregnancy: Maternal and fetal implications

Publication ,  Journal Article
James, AH; Brancazio, LR; Ortel, TL
Published in: Current Women S Health Reviews
February 1, 2006

Pregnancy is accompanied by altered levels of coagulation factors, which are likely responsible for an increased risk of thrombosis, including an increased risk of deep vein thrombosis, pulmonary embolism, stroke and myocardial infarction. Women with thrombophilia, an acquired or inherited predisposition to thrombosis, are at an even greater risk of thrombosis during pregnancy than other women. The presence of thrombophilia, which may protect women from blood loss at the time of childbirth, does not improve the outcome of pregnancy. Women with thrombophilia are more likely to experience placental abruption, preeclampsia, fetal growth restriction, stillbirth, and possibly recurrent miscarriage. There are no randomized trials of the use of anticoagulation to reduce maternal thromboembolism, but in women with thrombophilia and a history of thrombosis, anticoagulation is generally recommended. In women with thrombophilia and a history of poor pregnancy outcome, anticoagulation may improve fetal outcomes. © 2006 Bentham Science Publishers Ltd.

Duke Scholars

Published In

Current Women S Health Reviews

DOI

ISSN

1573-4048

Publication Date

February 1, 2006

Volume

2

Issue

1

Start / End Page

51 / 59

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 3215 Reproductive medicine
  • 0606 Physiology
 

Citation

APA
Chicago
ICMJE
MLA
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James, A. H., Brancazio, L. R., & Ortel, T. L. (2006). Thrombophilia in pregnancy: Maternal and fetal implications. Current Women S Health Reviews, 2(1), 51–59. https://doi.org/10.2174/157340406775486265
James, A. H., L. R. Brancazio, and T. L. Ortel. “Thrombophilia in pregnancy: Maternal and fetal implications.” Current Women S Health Reviews 2, no. 1 (February 1, 2006): 51–59. https://doi.org/10.2174/157340406775486265.
James AH, Brancazio LR, Ortel TL. Thrombophilia in pregnancy: Maternal and fetal implications. Current Women S Health Reviews. 2006 Feb 1;2(1):51–9.
James, A. H., et al. “Thrombophilia in pregnancy: Maternal and fetal implications.” Current Women S Health Reviews, vol. 2, no. 1, Feb. 2006, pp. 51–59. Scopus, doi:10.2174/157340406775486265.
James AH, Brancazio LR, Ortel TL. Thrombophilia in pregnancy: Maternal and fetal implications. Current Women S Health Reviews. 2006 Feb 1;2(1):51–59.
Journal cover image

Published In

Current Women S Health Reviews

DOI

ISSN

1573-4048

Publication Date

February 1, 2006

Volume

2

Issue

1

Start / End Page

51 / 59

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 3215 Reproductive medicine
  • 0606 Physiology