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Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.

Publication ,  Journal Article
Yao, L; Salvucci, O; Cardones, AR; Hwang, ST; Aoki, Y; De La Luz Sierra, M; Sajewicz, A; Pittaluga, S; Yarchoan, R; Tosato, G
Published in: Blood
December 1, 2003

Kaposi sarcoma (KS), the most common neoplasm in patients with AIDS, typically presents with multiple skin lesions characterized by "spindle cells," the vast majority of which are infected with KSHV (Kaposi sarcoma herpes virus, also named HHV-8). In patients with AIDS, the presence of cell-associated KSHV DNA in blood is predictive of subsequent KS development, but the mechanisms by which circulating KSHV-infected cells contribute to AIDS-KS pathogenesis are unclear. Here, we show that the chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed by skin capillary endothelium and displayed on the endothelial cell surface in association with heparan sulfate, can trigger specific arrest of KSHV-infected cells under physiologic shear flow conditions. Moreover, in the presence of soluble SDF-1 gradients, SDF-1 expressed on the endothelial barrier can promote transendothelial migration of KSHV-infected cells. By triggering specific adhesion of circulating KSHV-infected cells and favoring their entry into the extravascular cutaneous space, endothelial cell-associated SDF-1 in cutaneous capillaries may dictate the preferential occurrence of KS in the skin.

Duke Scholars

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 1, 2003

Volume

102

Issue

12

Start / End Page

3900 / 3905

Location

United States

Related Subject Headings

  • Umbilical Veins
  • Skin Neoplasms
  • Sarcoma, Kaposi
  • Receptors, CXCR4
  • Perfusion
  • Immunology
  • Humans
  • Herpesvirus 8, Human
  • Endothelial Cells
  • Chemokines, CXC
 

Citation

APA
Chicago
ICMJE
MLA
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Yao, L., Salvucci, O., Cardones, A. R., Hwang, S. T., Aoki, Y., De La Luz Sierra, M., … Tosato, G. (2003). Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. Blood, 102(12), 3900–3905. https://doi.org/10.1182/blood-2003-02-0641
Yao, Lei, Ombretta Salvucci, Adela R. Cardones, Sam T. Hwang, Yoshiyasu Aoki, Maria De La Luz Sierra, Agatha Sajewicz, Stefania Pittaluga, Robert Yarchoan, and Giovanna Tosato. “Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.Blood 102, no. 12 (December 1, 2003): 3900–3905. https://doi.org/10.1182/blood-2003-02-0641.
Yao L, Salvucci O, Cardones AR, Hwang ST, Aoki Y, De La Luz Sierra M, et al. Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. Blood. 2003 Dec 1;102(12):3900–5.
Yao, Lei, et al. “Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.Blood, vol. 102, no. 12, Dec. 2003, pp. 3900–05. Pubmed, doi:10.1182/blood-2003-02-0641.
Yao L, Salvucci O, Cardones AR, Hwang ST, Aoki Y, De La Luz Sierra M, Sajewicz A, Pittaluga S, Yarchoan R, Tosato G. Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. Blood. 2003 Dec 1;102(12):3900–3905.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 1, 2003

Volume

102

Issue

12

Start / End Page

3900 / 3905

Location

United States

Related Subject Headings

  • Umbilical Veins
  • Skin Neoplasms
  • Sarcoma, Kaposi
  • Receptors, CXCR4
  • Perfusion
  • Immunology
  • Humans
  • Herpesvirus 8, Human
  • Endothelial Cells
  • Chemokines, CXC