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Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population.

Publication ,  Journal Article
Lee, HR; Park, JS; Shin, S; Roh, EY; Yoon, JH; Han, KS; Kim, BJ; Storms, RW; Chao, NJ
Published in: Transfusion
January 2012

BACKGROUND: We analyzed neonatal factors that could affect hematopoietic variables of cord blood (CB) donated from Korean neonates. STUDY DESIGN AND METHODS: The numbers of total nucleated cells (TNCs), CD34+ cells, and CD34+ cells/TNCs of CB in neonates were compared according to sex, gestational age, birth weight, birth weight centile for gestational age, and ABO blood group. RESULTS: With 11,098 CB units analyzed, blood group O CB showed an increased number of TNCs, CD34+ cells, and CD34+ cells/TNCs compared with other blood groups. Although TNC counts were lower in males, no difference in the number of CD34+ cells was demonstrated because the number of CD34+ cells/TNCs was higher in males. An increase in the gestational age resulted in an increase in the number of TNCs and decreases in the number of CD34+ cells and CD34+ cells/TNCs. The numbers of TNCs, CD34+ cells, and CD34+ cells/TNCs increased according to increased birth weight centile as well as birth weight. CONCLUSION: CB with blood group O has unique hematologic variables in this large-scale analysis of Korean neonates, although the impact on the storage policies of CB banks or the clinical outcome of transplantation remains to be determined.

Duke Scholars

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Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

January 2012

Volume

52

Issue

1

Start / End Page

76 / 81

Location

United States

Related Subject Headings

  • Young Adult
  • Pregnancy
  • Male
  • Leukocytes
  • Korea
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Fetal Blood
  • Female
 

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Lee, H. R., Park, J. S., Shin, S., Roh, E. Y., Yoon, J. H., Han, K. S., … Chao, N. J. (2012). Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population. Transfusion, 52(1), 76–81. https://doi.org/10.1111/j.1537-2995.2011.03262.x
Lee, Hye Ryun, Jeong Su Park, Sue Shin, Eun Youn Roh, Jong Hyun Yoon, Kyou Sup Han, Byung Jae Kim, Robert W. Storms, and Nelson J. Chao. “Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population.Transfusion 52, no. 1 (January 2012): 76–81. https://doi.org/10.1111/j.1537-2995.2011.03262.x.
Lee, Hye Ryun, et al. “Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population.Transfusion, vol. 52, no. 1, Jan. 2012, pp. 76–81. Pubmed, doi:10.1111/j.1537-2995.2011.03262.x.
Lee HR, Park JS, Shin S, Roh EY, Yoon JH, Han KS, Kim BJ, Storms RW, Chao NJ. Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population. Transfusion. 2012 Jan;52(1):76–81.
Journal cover image

Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

January 2012

Volume

52

Issue

1

Start / End Page

76 / 81

Location

United States

Related Subject Headings

  • Young Adult
  • Pregnancy
  • Male
  • Leukocytes
  • Korea
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Fetal Blood
  • Female