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A recent update of pharmacogenomics in drug-induced severe skin reactions.

Publication ,  Journal Article
Wei, C-Y; Ko, T-M; Shen, C-Y; Chen, Y-T
Published in: Drug Metab Pharmacokinet
2012

In some adverse drug reactions (ADRs), genetic predisposition plays a significant role in pathogenesis, and the skin is the most frequently reported target. These severe cutaneous ADRs include bullous fixed drug eruptions (FDE), acute generalized exanthematous pustulosis (AGEP), drug-induced hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The putative contribution of individual effector cells in drug hypersensitivity is briefly mentioned. To trigger these drug hypersensitivities, certain class I HLA alleles (e.g., HLA-A and HLA-B alleles) and certain class II HLA alleles (e.g., HLA-DR alleles) have been recently found to be the genetic determinants. One of the best characterized examples mentioned in this article is HLA-B*1502 to determine the incidence of carbamazepine-induced SJS. How drugs are processed and presented by these HLA alleles to activate immune responses has been explained by several hypotheses. Further implication of pharmagenomic findings to prevent drug-induced severe skin reactions can be achieved by pre-screening putative risk HLA alleles before using drugs.

Duke Scholars

Published In

Drug Metab Pharmacokinet

DOI

EISSN

1880-0920

Publication Date

2012

Volume

27

Issue

1

Start / End Page

132 / 141

Location

England

Related Subject Headings

  • Stevens-Johnson Syndrome
  • Severity of Illness Index
  • Polymorphism, Genetic
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Keratinocytes
  • Humans
  • HLA Antigens
  • Drug Eruptions
  • Acute Generalized Exanthematous Pustulosis
 

Citation

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MLA
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Wei, C.-Y., Ko, T.-M., Shen, C.-Y., & Chen, Y.-T. (2012). A recent update of pharmacogenomics in drug-induced severe skin reactions. Drug Metab Pharmacokinet, 27(1), 132–141. https://doi.org/10.2133/dmpk.dmpk-11-rv-116
Wei, Chun-Yu, Tai-Ming Ko, Chen-Yang Shen, and Yuan-Tsong Chen. “A recent update of pharmacogenomics in drug-induced severe skin reactions.Drug Metab Pharmacokinet 27, no. 1 (2012): 132–41. https://doi.org/10.2133/dmpk.dmpk-11-rv-116.
Wei C-Y, Ko T-M, Shen C-Y, Chen Y-T. A recent update of pharmacogenomics in drug-induced severe skin reactions. Drug Metab Pharmacokinet. 2012;27(1):132–41.
Wei, Chun-Yu, et al. “A recent update of pharmacogenomics in drug-induced severe skin reactions.Drug Metab Pharmacokinet, vol. 27, no. 1, 2012, pp. 132–41. Pubmed, doi:10.2133/dmpk.dmpk-11-rv-116.
Wei C-Y, Ko T-M, Shen C-Y, Chen Y-T. A recent update of pharmacogenomics in drug-induced severe skin reactions. Drug Metab Pharmacokinet. 2012;27(1):132–141.
Journal cover image

Published In

Drug Metab Pharmacokinet

DOI

EISSN

1880-0920

Publication Date

2012

Volume

27

Issue

1

Start / End Page

132 / 141

Location

England

Related Subject Headings

  • Stevens-Johnson Syndrome
  • Severity of Illness Index
  • Polymorphism, Genetic
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Keratinocytes
  • Humans
  • HLA Antigens
  • Drug Eruptions
  • Acute Generalized Exanthematous Pustulosis