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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

Publication ,  Journal Article
Cho, YS; Chen, C-H; Hu, C; Long, J; Ong, RTH; Sim, X; Takeuchi, F; Wu, Y; Go, MJ; Yamauchi, T; Chang, Y-C; Kwak, SH; Ma, RCW; Yamamoto, K ...
Published in: Nat Genet
December 11, 2011
Published version (DOI) Link to item

We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.

Duke Scholars

Yuan-Tsong Chen
Author Yuan-Tsong Chen Pediatrics, Medical Genetics
Tien Yin Wong
Author Tien Yin Wong Ophthalmology
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Published In

Nat Genet

DOI

10.1038/ng.1019

EISSN

1546-1718

Publication Date

December 11, 2011

Volume

44

Issue

1

Start / End Page

67 / 72

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Diabetes Mellitus, Type 2
  • Developmental Biology
  • Chromosome Mapping
  • Case-Control Studies
  • Blood Glucose
  • Asian People
 

Citation

APA
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ICMJE
MLA
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Cho, Y. S., Chen, C.-H., Hu, C., Long, J., Ong, R. T. H., Sim, X., … Seielstad, M. (2011). Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet, 44(1), 67–72. https://doi.org/10.1038/ng.1019
Cho, Yoon Shin, Chien-Hsiun Chen, Cheng Hu, Jirong Long, Rick Twee Hee Ong, Xueling Sim, Fumihiko Takeuchi, et al. “Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.” Nat Genet 44, no. 1 (December 11, 2011): 67–72. https://doi.org/10.1038/ng.1019.
Cho YS, Chen C-H, Hu C, Long J, Ong RTH, Sim X, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67–72.
Cho, Yoon Shin, et al. “Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.” Nat Genet, vol. 44, no. 1, Dec. 2011, pp. 67–72. Pubmed, doi:10.1038/ng.1019.
Cho YS, Chen C-H, Hu C, Long J, Ong RTH, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang Y-C, Kwak SH, Ma RCW, Yamamoto K, Adair LS, Aung T, Cai Q, Chang L-C, Chen Y-T, Gao Y, Hu FB, Kim H-L, Kim S, Kim YJ, Lee JJ-M, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP-K, Tay WT, Tsai F-J, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang T-J, Bao Y, Hedman ÅK, Morris AP, McCarthy MI, DIAGRAM Consortium, MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang L-M, Chan JCN, Maeda S, Kadowaki T, Lee J-Y, Wu J-Y, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han B-G, Seielstad M. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67–72.

Published In

Nat Genet

DOI

10.1038/ng.1019

EISSN

1546-1718

Publication Date

December 11, 2011

Volume

44

Issue

1

Start / End Page

67 / 72

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Diabetes Mellitus, Type 2
  • Developmental Biology
  • Chromosome Mapping
  • Case-Control Studies
  • Blood Glucose
  • Asian People