Skip to main content

Genetic predisposition of life-threatening antiepileptic-induced skin reactions.

Publication ,  Journal Article
Chung, W-H; Hung, S-I; Chen, Y-T
Published in: Expert Opin Drug Saf
January 2010

IMPORTANCE OF THE FIELD: Recent advances in pharmacogenetic studies have uncovered increasingly more genes that predispose individuals to adverse drug reactions. Aromatic antiepileptic drugs (AEDs) are a frequent cause of severe cutaneous adverse reactions (SCAR). A strong genetic association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown in Han Chinese patients. AREAS COVERED IN THIS REVIEW: This article reviews and updates genetic information associated with CBZ and other AEDs causing SCAR in different ethnic populations. WHAT THE READER WILL GAIN: Independent studies from different countries confirmed that patients carrying the HLA-B*1502 are at high risk of SJS/TEN when exposed to CBZ. The US FDA and similar regulatory agencies in Canada and Taiwan have updated the CBZ drug label to include the genetic information. Available data also suggest that HLA-B*1502 is a risk allele for SJS/TEN caused by other aromatic AEDs with a similar structure to CBZ. TAKE HOME MESSAGE: Screening for HLA-B*1502 allele before starting treatment with CBZ is justified in patients from high-risk populations as recommended by regulatory agencies. Similar chemicals should also be avoided in individuals who test positive for HLA-B*1502.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Expert Opin Drug Saf

DOI

EISSN

1744-764X

Publication Date

January 2010

Volume

9

Issue

1

Start / End Page

15 / 21

Location

England

Related Subject Headings

  • Stevens-Johnson Syndrome
  • Skin Diseases
  • Racial Groups
  • Pharmacology & Pharmacy
  • Humans
  • HLA-B15 Antigen
  • HLA-B Antigens
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Drug Labeling
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chung, W.-H., Hung, S.-I., & Chen, Y.-T. (2010). Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf, 9(1), 15–21. https://doi.org/10.1517/14740330903427969
Chung, Wen-Hung, Shuen-Iu Hung, and Yuan-Tsong Chen. “Genetic predisposition of life-threatening antiepileptic-induced skin reactions.Expert Opin Drug Saf 9, no. 1 (January 2010): 15–21. https://doi.org/10.1517/14740330903427969.
Chung W-H, Hung S-I, Chen Y-T. Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf. 2010 Jan;9(1):15–21.
Chung, Wen-Hung, et al. “Genetic predisposition of life-threatening antiepileptic-induced skin reactions.Expert Opin Drug Saf, vol. 9, no. 1, Jan. 2010, pp. 15–21. Pubmed, doi:10.1517/14740330903427969.
Chung W-H, Hung S-I, Chen Y-T. Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf. 2010 Jan;9(1):15–21.

Published In

Expert Opin Drug Saf

DOI

EISSN

1744-764X

Publication Date

January 2010

Volume

9

Issue

1

Start / End Page

15 / 21

Location

England

Related Subject Headings

  • Stevens-Johnson Syndrome
  • Skin Diseases
  • Racial Groups
  • Pharmacology & Pharmacy
  • Humans
  • HLA-B15 Antigen
  • HLA-B Antigens
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Drug Labeling