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Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

Publication ,  Journal Article
Chan, DA; Kawahara, TLA; Sutphin, PD; Chang, HY; Chi, J-T; Giaccia, AJ
Published in: Cancer Cell
June 2, 2009

Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-kappaB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

June 2, 2009

Volume

15

Issue

6

Start / End Page

527 / 538

Location

United States

Related Subject Headings

  • Ribonuclease, Pancreatic
  • Procollagen-Proline Dioxygenase
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • NF-kappa B
  • Mice, SCID
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chan, D. A., Kawahara, T. L. A., Sutphin, P. D., Chang, H. Y., Chi, J.-T., & Giaccia, A. J. (2009). Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell, 15(6), 527–538. https://doi.org/10.1016/j.ccr.2009.04.010
Chan, Denise A., Tiara L. A. Kawahara, Patrick D. Sutphin, Howard Y. Chang, Jen-Tsan Chi, and Amato J. Giaccia. “Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.Cancer Cell 15, no. 6 (June 2, 2009): 527–38. https://doi.org/10.1016/j.ccr.2009.04.010.
Chan DA, Kawahara TLA, Sutphin PD, Chang HY, Chi J-T, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 2009 Jun 2;15(6):527–38.
Chan, Denise A., et al. “Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.Cancer Cell, vol. 15, no. 6, June 2009, pp. 527–38. Pubmed, doi:10.1016/j.ccr.2009.04.010.
Chan DA, Kawahara TLA, Sutphin PD, Chang HY, Chi J-T, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 2009 Jun 2;15(6):527–538.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

June 2, 2009

Volume

15

Issue

6

Start / End Page

527 / 538

Location

United States

Related Subject Headings

  • Ribonuclease, Pancreatic
  • Procollagen-Proline Dioxygenase
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • NF-kappa B
  • Mice, SCID
  • Mice
  • Male