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Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907.

Publication ,  Journal Article
Kornblith, AB; Lan, L; Archer, L; Partridge, A; Kimmick, G; Hudis, C; Winer, E; Casey, R; Bennett, S; Cohen, HJ; Muss, HB
Published in: J Clin Oncol
March 10, 2011

PURPOSE: A phase III trial (Cancer and Leukemia Group B CALGB-49907) was conducted to test whether older patients with early-stage breast cancer would have equivalent relapse-free and overall survival with capecitabine compared with standard chemotherapy. The quality of life (QoL) substudy tested whether capecitabine treatment would be associated with a better QoL than standard chemotherapy. PATIENTS AND METHODS: QoL was assessed in 350 patients randomly assigned to either standard chemotherapy (cyclophosphamide, methotrexate, and fluorouracil [CMF] or doxorubicin and cyclophosphamide [AC]; n = 182) or capecitabine (n = 168). Patients were interviewed by telephone before treatment (baseline), midtreatment, within 1 month post-treatment, and at 12, 18, and 24 months postbaseline by using questionnaires from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30), a breast systemic adverse effects scale (EORTC BR23), and the Hospital Anxiety and Depression Scale (HADS). RESULTS: Compared with patients who were treated with standard chemotherapy, patients who were treated with capecitabine had significantly better QoL, role function, and social function, fewer systemic adverse effects, less psychological distress, and less fatigue during and at the completion of treatment (P ≤ .005). Capecitabine treatment was associated with less nausea, vomiting, and constipation and with better appetite than standard treatment (P ≤ .004), but worse hand-foot syndrome and diarrhea (P < .005). These differences all resolved by 12 months. CONCLUSION: Standard chemotherapy was superior to capecitabine in improving relapse-free and overall survival for older women with early-stage breast cancer. Although capecitabine was associated with better QoL during treatment, QoL was similar for both groups at 1 year. The brief period of poorer QoL with standard treatment is a modest price to pay for a chance at improved survival.

Duke Scholars

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

March 10, 2011

Volume

29

Issue

8

Start / End Page

1022 / 1028

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Survival Analysis
  • Surveys and Questionnaires
  • Risk Factors
  • Risk Assessment
  • Quality of Life
  • Oncology & Carcinogenesis
  • Neoplasm Staging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kornblith, A. B., Lan, L., Archer, L., Partridge, A., Kimmick, G., Hudis, C., … Muss, H. B. (2011). Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907. J Clin Oncol, 29(8), 1022–1028. https://doi.org/10.1200/JCO.2010.29.9859
Kornblith, Alice B., Lan Lan, Laura Archer, Ann Partridge, Gretchen Kimmick, Clifford Hudis, Eric Winer, et al. “Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907.J Clin Oncol 29, no. 8 (March 10, 2011): 1022–28. https://doi.org/10.1200/JCO.2010.29.9859.
Kornblith AB, Lan L, Archer L, Partridge A, Kimmick G, Hudis C, et al. Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907. J Clin Oncol. 2011 Mar 10;29(8):1022–8.
Kornblith, Alice B., et al. “Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907.J Clin Oncol, vol. 29, no. 8, Mar. 2011, pp. 1022–28. Pubmed, doi:10.1200/JCO.2010.29.9859.
Kornblith AB, Lan L, Archer L, Partridge A, Kimmick G, Hudis C, Winer E, Casey R, Bennett S, Cohen HJ, Muss HB. Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907. J Clin Oncol. 2011 Mar 10;29(8):1022–1028.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

March 10, 2011

Volume

29

Issue

8

Start / End Page

1022 / 1028

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Survival Analysis
  • Surveys and Questionnaires
  • Risk Factors
  • Risk Assessment
  • Quality of Life
  • Oncology & Carcinogenesis
  • Neoplasm Staging