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Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity.

Publication ,  Journal Article
Allee, JE; Cotsarelis, G; Solky, B; Cook, JL
Published in: Dermatol Surg
August 2003

BACKGROUND: Trichilemmal carcinoma is an uncommon cutaneous malignancy that is thought to be the malignant counterpart of the trichilemmoma. Despite histologic features such as pronounced cytologic atypia, trichilemmal carcinoma is often described as having a rather benign clinical course. Cases of tumor recurrence after therapy are uncommon, and tumor neurotropism has never been described. OBJECTIVE: A case of multiply recurrent trichilemmal carcinoma with perineural invasion is described. The outer root sheath differentiation of this neoplasm is confirmed with the use of novel antibodies directed toward cytokeratins that are expressed in this area of the hair follicle. METHODS: The trichilemmal carcinoma was excised using the Mohs surgical technique. Tissue obtained during the extirpation of the tumor was subjected to immunohistochemical staining for cytokeratin 15, cytokeratin 17, and c-erb-B2. RESULTS: Tumor neurotropism was noted. The trichilemmal carcinoma demonstrated abundant cytoplasmic staining for cytokeratin 17 and c-erb-B2. CONCLUSIONS: In distinction to previous reports, this case reveals that trichilemmal carcinoma can demonstrate significant biological aggression, as reflected by tumor neurotropism and by failure to respond to multiple surgical excisions. The purported outer root sheath differentiation of this neoplasm is confirmed with the use of novel immunohistochemical staining. This immunohistochemical staining may be useful in differentiating trichilemmal carcinoma from other clear cell neoplasms.

Duke Scholars

Published In

Dermatol Surg

DOI

ISSN

1076-0512

Publication Date

August 2003

Volume

29

Issue

8

Start / End Page

886 / 889

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Perineum
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Mohs Surgery
  • Male
  • Keratins
  • Immunohistochemistry
  • Humans
  • Dermatology & Venereal Diseases
 

Citation

APA
Chicago
ICMJE
MLA
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Allee, J. E., Cotsarelis, G., Solky, B., & Cook, J. L. (2003). Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity. Dermatol Surg, 29(8), 886–889. https://doi.org/10.1046/j.1524-4725.2003.29241.x
Allee, Julie E., George Cotsarelis, Benjamin Solky, and Jonathan L. Cook. “Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity.Dermatol Surg 29, no. 8 (August 2003): 886–89. https://doi.org/10.1046/j.1524-4725.2003.29241.x.
Allee JE, Cotsarelis G, Solky B, Cook JL. Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity. Dermatol Surg. 2003 Aug;29(8):886–9.
Allee, Julie E., et al. “Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity.Dermatol Surg, vol. 29, no. 8, Aug. 2003, pp. 886–89. Pubmed, doi:10.1046/j.1524-4725.2003.29241.x.
Allee JE, Cotsarelis G, Solky B, Cook JL. Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity. Dermatol Surg. 2003 Aug;29(8):886–889.
Journal cover image

Published In

Dermatol Surg

DOI

ISSN

1076-0512

Publication Date

August 2003

Volume

29

Issue

8

Start / End Page

886 / 889

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Perineum
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Mohs Surgery
  • Male
  • Keratins
  • Immunohistochemistry
  • Humans
  • Dermatology & Venereal Diseases