Role of vasoactive mediators in the pathogenesis of Chagas' disease.
Publication
, Journal Article
Mukherjee, S; Huang, H; Weiss, LM; Costa, S; Scharfstein, J; Tanowitz, HB
Published in: Front Biosci
May 1, 2003
This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.
Duke Scholars
Published In
Front Biosci
DOI
ISSN
1093-9946
Publication Date
May 1, 2003
Volume
8
Start / End Page
e410 / e419
Location
United States
Related Subject Headings
- Molecular Sequence Data
- Kinins
- Humans
- Chagas Disease
- Biochemistry & Molecular Biology
- Animals
- Amino Acid Sequence
- 1116 Medical Physiology
- 1112 Oncology and Carcinogenesis
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Mukherjee, S., Huang, H., Weiss, L. M., Costa, S., Scharfstein, J., & Tanowitz, H. B. (2003). Role of vasoactive mediators in the pathogenesis of Chagas' disease. Front Biosci, 8, e410–e419. https://doi.org/10.2741/1103
Mukherjee, Shankar, Huan Huang, Louis M. Weiss, Sylvia Costa, Julio Scharfstein, and Herbert B. Tanowitz. “Role of vasoactive mediators in the pathogenesis of Chagas' disease.” Front Biosci 8 (May 1, 2003): e410–19. https://doi.org/10.2741/1103.
Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Front Biosci. 2003 May 1;8:e410–9.
Mukherjee, Shankar, et al. “Role of vasoactive mediators in the pathogenesis of Chagas' disease.” Front Biosci, vol. 8, May 2003, pp. e410–19. Pubmed, doi:10.2741/1103.
Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Front Biosci. 2003 May 1;8:e410–e419.
Published In
Front Biosci
DOI
ISSN
1093-9946
Publication Date
May 1, 2003
Volume
8
Start / End Page
e410 / e419
Location
United States
Related Subject Headings
- Molecular Sequence Data
- Kinins
- Humans
- Chagas Disease
- Biochemistry & Molecular Biology
- Animals
- Amino Acid Sequence
- 1116 Medical Physiology
- 1112 Oncology and Carcinogenesis
- 0601 Biochemistry and Cell Biology