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New targeted therapies for non-small-cell lung cancer: a focus on the epidermal growth factor receptor.

Publication ,  Journal Article
Crawford, J
Published in: J Natl Compr Canc Netw
January 2003

Advances in chemotherapy and multimodality treatments of patients with non-small-cell lung cancer (NSCLC) have improved outcomes for these patients over the past decade. Unfortunately, gains have been modest, and new therapeutic strategies are eagerly awaited. Therapies that target receptors vital to the proliferation and survival of cancer cells are particularly attractive areas of research. The epidermal growth factor receptor (EGFR) is widely expressed in NSCLC. Preclinical studies demonstrate that inhibition of EGFR using antibodies or tyrosine kinase inhibitors has led to growth inhibition and tumor regression in a variety of models. A number of agents are currently in clinical trials; the most information in NSCLC is currently available on the tyrosine kinase inhibitors. Phase II trials involving patients with advanced NSCLC and whose disease is progressive after chemotherapy have demonstrated clear clinical benefit. Studies are ongoing, integrating EGFR-targeted therapy with chemotherapy and radiation in patients with earlier stage NSCLC, as well as in chemoprevention. In all of these settings, a further understanding of the biology of EGFR in relationship to other cellular events will be critical in optimizing therapeutic approaches with these novel agents.

Duke Scholars

Published In

J Natl Compr Canc Netw

ISSN

1540-1405

Publication Date

January 2003

Volume

1 Suppl 1

Start / End Page

S78 / S86

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • ErbB Receptors
  • Clinical Trials as Topic
  • Carcinoma, Non-Small-Cell Lung
  • Antineoplastic Agents
  • 4203 Health services and systems
  • 3211 Oncology and carcinogenesis
 

Citation

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MLA
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Crawford, Jeffrey. “New targeted therapies for non-small-cell lung cancer: a focus on the epidermal growth factor receptor.J Natl Compr Canc Netw 1 Suppl 1 (January 2003): S78–86.
Crawford, Jeffrey. “New targeted therapies for non-small-cell lung cancer: a focus on the epidermal growth factor receptor.J Natl Compr Canc Netw, vol. 1 Suppl 1, Jan. 2003, pp. S78–86.

Published In

J Natl Compr Canc Netw

ISSN

1540-1405

Publication Date

January 2003

Volume

1 Suppl 1

Start / End Page

S78 / S86

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • ErbB Receptors
  • Clinical Trials as Topic
  • Carcinoma, Non-Small-Cell Lung
  • Antineoplastic Agents
  • 4203 Health services and systems
  • 3211 Oncology and carcinogenesis