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Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer.

Publication ,  Journal Article
Einhorn, LH; Crawford, J; Birch, R; Omura, G; Johnson, DH; Greco, FA
Published in: J Clin Oncol
March 1988

From June 1982 through October 1985, the Southeastern Cancer Study Group randomized patients with limited small-cell lung cancer (SCLC) to cyclophosphamide plus doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH) plus vincristine (CAV) for six cycles v CAV plus concomitant thoracic irradiation as induction therapy. Patients achieving either a complete or partial response and remaining in remission after completion of induction therapy were subsequently randomized to consolidation chemotherapy consisting of cisplatin 20 mg/m2 X 4 plus etoposide (VP-16) 100 mg/m2 X 4 every 4 weeks for two courses v no further therapy. There were 160 patients entered on the consolidation phase and 148 were fully evaluable. The median survival for patients randomized to cisplatin plus VP-16 (PVP16) from start of CAV chemotherapy was 97.7 weeks, compared with 68 weeks for the no-consolidation arm (P = .0094). PVP16 consolidation also significantly increased the duration of remission, with median durations of 49 weeks v 28 weeks (P = .0008). The median durations for partial remission were 41 weeks v 23 weeks (P = .013), and for complete remission, 52 weeks v 30.5 weeks (P = .0091). Furthermore, 18 patients on PVP16 consolidation remain in a continuous complete remission for 12+ months and 13 of these are continuously disease free 2+ years. Eight patients randomized to no consolidation remain in a continuous complete remission, with only four patients disease free 2+ years. PVP16 consolidation has significantly improved the duration of remission and overall survival and appears capable of improving the cure rate in limited SCLC.

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Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

March 1988

Volume

6

Issue

3

Start / End Page

451 / 456

Location

United States

Related Subject Headings

  • Vincristine
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Etoposide
  • Drug Resistance
  • Doxorubicin
 

Citation

APA
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ICMJE
MLA
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Einhorn, L. H., Crawford, J., Birch, R., Omura, G., Johnson, D. H., & Greco, F. A. (1988). Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer. J Clin Oncol, 6(3), 451–456. https://doi.org/10.1200/JCO.1988.6.3.451
Einhorn, L. H., J. Crawford, R. Birch, G. Omura, D. H. Johnson, and F. A. Greco. “Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer.J Clin Oncol 6, no. 3 (March 1988): 451–56. https://doi.org/10.1200/JCO.1988.6.3.451.
Einhorn LH, Crawford J, Birch R, Omura G, Johnson DH, Greco FA. Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer. J Clin Oncol. 1988 Mar;6(3):451–6.
Einhorn, L. H., et al. “Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer.J Clin Oncol, vol. 6, no. 3, Mar. 1988, pp. 451–56. Pubmed, doi:10.1200/JCO.1988.6.3.451.
Einhorn LH, Crawford J, Birch R, Omura G, Johnson DH, Greco FA. Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer. J Clin Oncol. 1988 Mar;6(3):451–456.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

March 1988

Volume

6

Issue

3

Start / End Page

451 / 456

Location

United States

Related Subject Headings

  • Vincristine
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Etoposide
  • Drug Resistance
  • Doxorubicin