Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.
Publication
, Journal Article
Calabrese, P; Durrett, R
Published in: Molecular biology and evolution
May 2003
We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long microsatellites have a bias toward contractions.
Duke Scholars
Published In
Molecular biology and evolution
DOI
EISSN
1537-1719
ISSN
0737-4038
Publication Date
May 2003
Volume
20
Issue
5
Start / End Page
715 / 725
Related Subject Headings
- Mutation
- Models, Genetic
- Likelihood Functions
- Humans
- Evolutionary Biology
- Evolution, Molecular
- Drosophila
- Dinucleotide Repeats
- Animals
- 3105 Genetics
Citation
APA
Chicago
ICMJE
MLA
NLM
Calabrese, P., & Durrett, R. (2003). Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes. Molecular Biology and Evolution, 20(5), 715–725. https://doi.org/10.1093/molbev/msg084
Calabrese, Peter, and Rick Durrett. “Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.” Molecular Biology and Evolution 20, no. 5 (May 2003): 715–25. https://doi.org/10.1093/molbev/msg084.
Calabrese P, Durrett R. Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes. Molecular biology and evolution. 2003 May;20(5):715–25.
Calabrese, Peter, and Rick Durrett. “Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.” Molecular Biology and Evolution, vol. 20, no. 5, May 2003, pp. 715–25. Epmc, doi:10.1093/molbev/msg084.
Calabrese P, Durrett R. Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes. Molecular biology and evolution. 2003 May;20(5):715–725.
Published In
Molecular biology and evolution
DOI
EISSN
1537-1719
ISSN
0737-4038
Publication Date
May 2003
Volume
20
Issue
5
Start / End Page
715 / 725
Related Subject Headings
- Mutation
- Models, Genetic
- Likelihood Functions
- Humans
- Evolutionary Biology
- Evolution, Molecular
- Drosophila
- Dinucleotide Repeats
- Animals
- 3105 Genetics