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Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.

Publication ,  Journal Article
Calabrese, P; Durrett, R
Published in: Molecular biology and evolution
May 2003

We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long microsatellites have a bias toward contractions.

Duke Scholars

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

May 2003

Volume

20

Issue

5

Start / End Page

715 / 725

Related Subject Headings

  • Mutation
  • Models, Genetic
  • Likelihood Functions
  • Humans
  • Evolutionary Biology
  • Evolution, Molecular
  • Drosophila
  • Dinucleotide Repeats
  • Animals
  • 3105 Genetics
 

Citation

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Chicago
ICMJE
MLA
NLM
Calabrese, P., & Durrett, R. (2003). Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes. Molecular Biology and Evolution, 20(5), 715–725. https://doi.org/10.1093/molbev/msg084
Calabrese, Peter, and Rick Durrett. “Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.Molecular Biology and Evolution 20, no. 5 (May 2003): 715–25. https://doi.org/10.1093/molbev/msg084.
Calabrese P, Durrett R. Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes. Molecular biology and evolution. 2003 May;20(5):715–25.
Calabrese, Peter, and Rick Durrett. “Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.Molecular Biology and Evolution, vol. 20, no. 5, May 2003, pp. 715–25. Epmc, doi:10.1093/molbev/msg084.
Calabrese P, Durrett R. Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes. Molecular biology and evolution. 2003 May;20(5):715–725.
Journal cover image

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

May 2003

Volume

20

Issue

5

Start / End Page

715 / 725

Related Subject Headings

  • Mutation
  • Models, Genetic
  • Likelihood Functions
  • Humans
  • Evolutionary Biology
  • Evolution, Molecular
  • Drosophila
  • Dinucleotide Repeats
  • Animals
  • 3105 Genetics