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A new stochastic model of microsatellite evolution

Publication ,  Journal Article
Durrett, R; Kruglyak, S
Published in: Journal of Applied Probability
January 1, 1999

We introduce a continuous-time Markov chain model for the evolution of microsatellites, simple sequence repeats in DNA. We prove the existence of a unique stationary distribution for our model, and fit the model to data from approximately 106 base pairs of DNA from fruit flies, mice, and humans. The slippage rates from the best fit for our model are consistent with experimental findings.

Duke Scholars

Published In

Journal of Applied Probability

DOI

ISSN

0021-9002

Publication Date

January 1, 1999

Volume

36

Issue

3

Start / End Page

621 / 631

Related Subject Headings

  • Statistics & Probability
  • 4905 Statistics
  • 4901 Applied mathematics
  • 0104 Statistics
  • 0102 Applied Mathematics
 

Citation

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Durrett, R., & Kruglyak, S. (1999). A new stochastic model of microsatellite evolution. Journal of Applied Probability, 36(3), 621–631. https://doi.org/10.1017/S0021900200017447
Durrett, R., and S. Kruglyak. “A new stochastic model of microsatellite evolution.” Journal of Applied Probability 36, no. 3 (January 1, 1999): 621–31. https://doi.org/10.1017/S0021900200017447.
Durrett R, Kruglyak S. A new stochastic model of microsatellite evolution. Journal of Applied Probability. 1999 Jan 1;36(3):621–31.
Durrett, R., and S. Kruglyak. “A new stochastic model of microsatellite evolution.” Journal of Applied Probability, vol. 36, no. 3, Jan. 1999, pp. 621–31. Scopus, doi:10.1017/S0021900200017447.
Durrett R, Kruglyak S. A new stochastic model of microsatellite evolution. Journal of Applied Probability. 1999 Jan 1;36(3):621–631.
Journal cover image

Published In

Journal of Applied Probability

DOI

ISSN

0021-9002

Publication Date

January 1, 1999

Volume

36

Issue

3

Start / End Page

621 / 631

Related Subject Headings

  • Statistics & Probability
  • 4905 Statistics
  • 4901 Applied mathematics
  • 0104 Statistics
  • 0102 Applied Mathematics