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Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income.

Publication ,  Journal Article
McBride, CM; Bepler, G; Lipkus, IM; Lyna, P; Samsa, G; Albright, J; Datta, S; Rimer, BK
Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
June 2002

Markers of genetic susceptibility to tobacco-related cancers could personalize harms of smoking and motivate cessation. Our objective was to assess whether a multicomponent intervention that included feedback about genetic susceptibility to lung cancer increased risk perceptions and rates of smoking cessation compared with a standard cessation intervention.Our design was a two-arm trial with eligible smokers randomized in a 1:2 ratio to Enhanced Usual Care or Biomarker Feedback (BF). Surveys were conducted at baseline, 6, and 12 months later. The setting was an inner city community health clinic. African-American patients who were current smokers (n = 557) were identified by chart abstraction and provider referral. All smokers received a self-help manual and, if appropriate, nicotine patches. Smokers in the BF arm also were offered a blood test for genotyping the GST(3) gene (GSTM1), sent a test result booklet, and called up to four times by a health educator. Prevalent abstinence was assessed by self-report of having smoked no cigarettes in the prior 7 days at the 6- and 12-month follow-ups and sustained abstinence, i.e., not smoking at either follow-up or in-between.Smoking cessation was greater for the BF arm than the Enhanced Usual Care arm (19% versus 10%, respectively; P < 0.006) at 6 months but not at 12 months.Smokers agreed to genetic feedback as part of a multicomponent cessation program. Although the program increased short-term cessation rates compared with standard intervention, genetic feedback of susceptibility may not benefit smokers with high baseline risk perceptions.

Duke Scholars

Published In

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

EISSN

1538-7755

ISSN

1055-9965

Publication Date

June 2002

Volume

11

Issue

6

Start / End Page

521 / 528

Related Subject Headings

  • Treatment Outcome
  • Smoking Cessation
  • Patient Education as Topic
  • Motivation
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Feedback, Psychological
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McBride, C. M., Bepler, G., Lipkus, I. M., Lyna, P., Samsa, G., Albright, J., … Rimer, B. K. (2002). Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 11(6), 521–528.
McBride, Colleen M., Gerold Bepler, Isaac M. Lipkus, Pauline Lyna, Greg Samsa, Jennifer Albright, Santanu Datta, and Barbara K. Rimer. “Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income.Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 11, no. 6 (June 2002): 521–28.
McBride CM, Bepler G, Lipkus IM, Lyna P, Samsa G, Albright J, et al. Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2002 Jun;11(6):521–8.
McBride, Colleen M., et al. “Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income.Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, vol. 11, no. 6, June 2002, pp. 521–28.
McBride CM, Bepler G, Lipkus IM, Lyna P, Samsa G, Albright J, Datta S, Rimer BK. Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2002 Jun;11(6):521–528.

Published In

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

EISSN

1538-7755

ISSN

1055-9965

Publication Date

June 2002

Volume

11

Issue

6

Start / End Page

521 / 528

Related Subject Headings

  • Treatment Outcome
  • Smoking Cessation
  • Patient Education as Topic
  • Motivation
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Feedback, Psychological