
A new structural state of myosin.
Publication
, Journal Article
Kull, FJ; Endow, SA
Published in: Trends Biochem Sci
March 2004
The mechanism by which motor proteins hydrolyze ATP and move along cytoskeletal filaments is still unknown. One approach to deciphering the mechanism is to correlate steps of ATP hydrolysis with structural states of the motors to determine the changes the motors undergo during the hydrolysis cycle. Unfortunately, available crystal structures represent only a few steps of the cycle and obtaining atomic structures that represent the motors bound to their filament has been difficult. Now, two new myosin crystal structures have been reported that show features expected for myosin motors bound in rigor to actin. The two new structures show changes at both the actin-binding surface and the active site that have not been observed previously.
Duke Scholars
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
March 2004
Volume
29
Issue
3
Start / End Page
103 / 106
Location
England
Related Subject Headings
- Protein Conformation
- Protein Binding
- Myosins
- Molecular Motor Proteins
- Models, Molecular
- Models, Biological
- Kinesins
- Hydrolysis
- Developmental Biology
- Adenosine Triphosphate
Citation
APA
Chicago
ICMJE
MLA
NLM
Kull, F. J., & Endow, S. A. (2004). A new structural state of myosin. Trends Biochem Sci, 29(3), 103–106. https://doi.org/10.1016/j.tibs.2004.01.001
Kull, F Jon, and Sharyn A. Endow. “A new structural state of myosin.” Trends Biochem Sci 29, no. 3 (March 2004): 103–6. https://doi.org/10.1016/j.tibs.2004.01.001.
Kull FJ, Endow SA. A new structural state of myosin. Trends Biochem Sci. 2004 Mar;29(3):103–6.
Kull, F. Jon, and Sharyn A. Endow. “A new structural state of myosin.” Trends Biochem Sci, vol. 29, no. 3, Mar. 2004, pp. 103–06. Pubmed, doi:10.1016/j.tibs.2004.01.001.
Kull FJ, Endow SA. A new structural state of myosin. Trends Biochem Sci. 2004 Mar;29(3):103–106.

Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
March 2004
Volume
29
Issue
3
Start / End Page
103 / 106
Location
England
Related Subject Headings
- Protein Conformation
- Protein Binding
- Myosins
- Molecular Motor Proteins
- Models, Molecular
- Models, Biological
- Kinesins
- Hydrolysis
- Developmental Biology
- Adenosine Triphosphate