Mutant alleles of the meiotic locus, mei-9, differ in degree of effects on rod chromosome magnification and ring chromosome transmission in Drosophila.
Two mutant alleles of the meiotic locus, mei-9, have been examined for their effect on magnification of a rod Xbb chromosome and transmission of a ring Xbb chromosome under magnifying conditions. Our results indicate that the effects of these two mutations are allele-specific: mei-9a strongly inhibits both rod chromosome magnification and ring chromosome loss under magnifying conditions, while mei-9b has a smaller inhibitory effect on rod chromosome magnification and on the transmission of ring chromosomes under magnifying conditions. These observations can be explained by a difference in leakiness between the two alleles. Our results demonstrate that mutants defective in excision repair and repair replication inhibit ribosomal gene magnification. This suggests that a component of the excision repair pathway is involved in the process of magnification.
Duke Scholars
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DOI
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- X Chromosome
- Ring Chromosomes
- Mutation
- Meiosis
- Male
- Female
- Evolutionary Biology
- Drosophila melanogaster
- Animals
- Alleles
Citation
Published In
DOI
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- X Chromosome
- Ring Chromosomes
- Mutation
- Meiosis
- Male
- Female
- Evolutionary Biology
- Drosophila melanogaster
- Animals
- Alleles