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One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster.

Publication ,  Journal Article
Endow, SA; Komma, DJ
Published in: Genetics
October 1986

Bobbed lethal (bbl) chromosomes carry too few ribosomal genes for homozygous flies to be viable. Reversion of bbl chromosomes to bb or nearly bb+ occurs under magnifying conditions at a low frequency in a single generation. These reversions occur too rapidly to be accounted for by single unequal sister chromatid exchanges and seem unlikely to be due to multiple sister strand exchanges within a given cell lineage. Analysis of several one-step revertants indicates that they are X-Y recombinant chromosomes which probably arise from X-Y recombination at bb. The addition of ribosomal genes from the Y chromosome to the bbl chromosome explains the more rapid reversion of the bbl chromosome than is permitted by single events of unequal sister chromatid exchange. Analysis of stepwise bbl magnified chromosomes, which were selected over a period of 4-9 magnifying generations, shows ribosomal gene patterns that are closely similar to each other. Similarity in rDNA pattern among stepwise magnified products of the same parental chromosome is consistent with reversion by a mechanism of unequal sister strand exchange.

Duke Scholars

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

October 1986

Volume

114

Issue

2

Start / End Page

511 / 523

Location

United States

Related Subject Headings

  • Nucleic Acid Hybridization
  • Male
  • Homozygote
  • Genes, Lethal
  • Female
  • Drosophila melanogaster
  • Developmental Biology
  • DNA
  • Chromosome Mapping
  • Animals
 

Citation

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Endow, S. A., & Komma, D. J. (1986). One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster. Genetics, 114(2), 511–523. https://doi.org/10.1093/genetics/114.2.511
Endow, S. A., and D. J. Komma. “One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster.Genetics 114, no. 2 (October 1986): 511–23. https://doi.org/10.1093/genetics/114.2.511.
Endow, S. A., and D. J. Komma. “One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster.Genetics, vol. 114, no. 2, Oct. 1986, pp. 511–23. Pubmed, doi:10.1093/genetics/114.2.511.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

October 1986

Volume

114

Issue

2

Start / End Page

511 / 523

Location

United States

Related Subject Headings

  • Nucleic Acid Hybridization
  • Male
  • Homozygote
  • Genes, Lethal
  • Female
  • Drosophila melanogaster
  • Developmental Biology
  • DNA
  • Chromosome Mapping
  • Animals