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Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.

Publication ,  Journal Article
Weber, U; Eroglu, C; Mlodzik, M
Published in: Dev Cell
October 2003

The role of phospholipids in the regulation of membrane trafficking and signaling is largely unknown. Phosphatidylcholine (PC) is a main component of the plasma membrane. Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition with reduced PC and increased phosphatidylinositol (PI) levels. Phenotypic features of dCCT1 indicate that the enzyme is not required for cell survival, but serves a role in endocytic regulation. CCT1- cells show an increase in endocytosis and enlarged endosomal compartments, whereas lysosomal delivery is unchanged. As a consequence, an increase in endocytic localization of EGF receptor (Egfr) and Notch is observed, and this correlates with a reduction in signaling strength and leads to patterning defects. A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic.

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Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

October 2003

Volume

5

Issue

4

Start / End Page

559 / 570

Location

United States

Related Subject Headings

  • Transgenes
  • Subcellular Fractions
  • Signal Transduction
  • Sequence Homology, Amino Acid
  • Receptors, Notch
  • Protein Transport
  • Protein Structure, Tertiary
  • Phospholipids
  • Phenotype
  • Mutation
 

Citation

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Weber, U., Eroglu, C., & Mlodzik, M. (2003). Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell, 5(4), 559–570. https://doi.org/10.1016/s1534-5807(03)00273-9
Weber, Ursula, Cagla Eroglu, and Marek Mlodzik. “Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.Dev Cell 5, no. 4 (October 2003): 559–70. https://doi.org/10.1016/s1534-5807(03)00273-9.
Weber, Ursula, et al. “Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.Dev Cell, vol. 5, no. 4, Oct. 2003, pp. 559–70. Pubmed, doi:10.1016/s1534-5807(03)00273-9.
Journal cover image

Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

October 2003

Volume

5

Issue

4

Start / End Page

559 / 570

Location

United States

Related Subject Headings

  • Transgenes
  • Subcellular Fractions
  • Signal Transduction
  • Sequence Homology, Amino Acid
  • Receptors, Notch
  • Protein Transport
  • Protein Structure, Tertiary
  • Phospholipids
  • Phenotype
  • Mutation