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Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells.

Publication ,  Journal Article
Cheung, KS; Li, JK; Falletta, JM; Wagner, JL; Lang, DJ
Published in: Infect Immun
July 1981

Mice were studied for 3 to 4 months after murine cytomegalovirus (MCMV) infection. Serial hematological parameters were evaluated. It was found that MCMV infection of mice were accompanied by the appearance of many atypical lymphocytes similar to those seen in association with the hematological features of mononucleosis associated with human CMV infection. Certain functions of splenocytes were studied in infected and uninfected animals during the 4 months after MCMV infection. Three periods were identifiable by the functional response of splenocytes during the course of MCMV infection. The initial phase was characterized by an elevated response of splenocytes to a T cell mitogen and a B cell mitogen (phytohemagglutinin and lipopolysaccharide, respectively). The intermediate phase was marked by productive virus replication in the salivary gland, injury to lymphoid elements, a depressed response of splenocytes to mitogens (phytohemagglutinin and lipopolysaccharide), and decreased humoral splenocytes to phytohemagglutinin stimulation was again increased, and a nonproductive latent infection was established. Study by scanning electron microscopy of splenocytes during the course of infection revealed morphological changes which were correlated with functional alterations.

Duke Scholars

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

July 1981

Volume

33

Issue

1

Start / End Page

239 / 249

Location

United States

Related Subject Headings

  • Viremia
  • Spleen
  • Specific Pathogen-Free Organisms
  • Microbiology
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphocytes
  • Lymphocyte Activation
  • Leukocyte Count
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cheung, K. S., Li, J. K., Falletta, J. M., Wagner, J. L., & Lang, D. J. (1981). Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. Infect Immun, 33(1), 239–249. https://doi.org/10.1128/iai.33.1.239-249.1981
Cheung, K. S., J. K. Li, J. M. Falletta, J. L. Wagner, and D. J. Lang. “Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells.Infect Immun 33, no. 1 (July 1981): 239–49. https://doi.org/10.1128/iai.33.1.239-249.1981.
Cheung KS, Li JK, Falletta JM, Wagner JL, Lang DJ. Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. Infect Immun. 1981 Jul;33(1):239–49.
Cheung, K. S., et al. “Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells.Infect Immun, vol. 33, no. 1, July 1981, pp. 239–49. Pubmed, doi:10.1128/iai.33.1.239-249.1981.
Cheung KS, Li JK, Falletta JM, Wagner JL, Lang DJ. Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. Infect Immun. 1981 Jul;33(1):239–249.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

July 1981

Volume

33

Issue

1

Start / End Page

239 / 249

Location

United States

Related Subject Headings

  • Viremia
  • Spleen
  • Specific Pathogen-Free Organisms
  • Microbiology
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphocytes
  • Lymphocyte Activation
  • Leukocyte Count